Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells

Oxidative stress and inflammation are two interrelated biological events implicated in the pathogenesis of many diseases. Reactive oxygen species (ROS) produced under oxidative stress play a key role in pathological conditions. Inhibition of p22phox, an indispensable component of the NADPH oxidase (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2015-09, Vol.5 (1), p.14362-14362, Article 14362
Hauptverfasser:	Qiu, Yiguo, Tao, Lifei, Lei, Chunyan, Wang, Jiaming, Yang, Peizeng, Li, Qiuhong, Lei, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 13/89 13/95 38/77 631/250/256 692/308/1426 Angiotensin II - pharmacology Cell Line Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation Humanities and Social Sciences Humans Inflammation Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-8 - antagonists & inhibitors Interleukin-8 - genetics Interleukin-8 - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism multidisciplinary NADPH Oxidase 1 NADPH Oxidase 2 NADPH Oxidase 4 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism Oxidative Stress p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Primary Cell Culture Retinal Pigment Epithelium - cytology Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!