Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells

Adipose derived Mesenchymal stem cells (AMSCs) are able to expand in vitro and undergo differentiation into multiple cell lineages, yet have low immunogenicity while exhibiting several immunoregulatory characteristics. We sought to investigate the immunomodulatory mechanisms of AMSCs to better under...

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Veröffentlicht in:	Scientific reports 2015-09, Vol.5 (1), p.14284-14284, Article 14284
Hauptverfasser:	Xishan, Zhu, Bin, Zhang, Haiyue, Zhao, Xiaowei, Dou, Jingwen, Bai, Guojun, Zhang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/68/2486 692/699/67/2324 Adipose Tissue - cytology Apoptosis - genetics Apoptosis - immunology Cell Communication - immunology Cell culture Cell Differentiation - drug effects Cell Movement Chondrogenesis - immunology Cytokines - biosynthesis Gene Expression Humanities and Social Sciences Humans Immunogenicity Immunomodulation Immunomodulators Immunophenotyping Immunoregulation Immunosuppressive agents Inflammation Intercellular Signaling Peptides and Proteins - genetics Interferon Interferon-gamma - pharmacology Jagged-2 Protein Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Lymphocytes Major Histocompatibility Complex - genetics Major Histocompatibility Complex - immunology Membrane Proteins - genetics Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme multidisciplinary Phenotype RNA-mediated interference Science Skin & tissue grafts Stem cells T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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