Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation

Ranbp1, a Ran GTPase-binding protein implicated in nuclear/cytoplasmic trafficking, is included within the DiGeorge/22q11.2 Deletion Syndrome (22q11.2 DS) critical region associated with behavioral impairments including autism and schizophrenia. Ranbp1 is highly expressed in the developing forebrain...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2015-10, Vol.25 (10), p.3977-3993
Hauptverfasser:	Paronett, Elizabeth M, Meechan, Daniel W, Karpinski, Beverly A, LaMantia, Anthony-Samuel, Maynard, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity Cell Proliferation - genetics Cerebral Cortex - embryology Cerebral Cortex - physiopathology DiGeorge Syndrome - embryology DiGeorge Syndrome - genetics DiGeorge Syndrome - physiopathology Lateral Ventricles - embryology Lateral Ventricles - physiopathology Mice Mice, Inbred C57BL Mice, Knockout Microcephaly - genetics Neural Stem Cells - physiology Neuroepithelial Cells - physiology Neurogenesis - genetics Nuclear Proteins - genetics Nuclear Proteins - physiology
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