Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse

Idiopathic epilepsies have frequently been linked to mutations in voltage-gated channels (channelopathies); recently, mutations in several genes encoding presynaptic proteins have been shown to cause epilepsy in humans and mice, indicating that epilepsy can also be considered a synaptopathy. However...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2015-10, Vol.25 (10), p.3356-3368
Hauptverfasser:	Medrihan, Lucian, Ferrea, Enrico, Greco, Barbara, Baldelli, Pietro, Benfenati, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Excitatory Postsynaptic Potentials GABA Agonists - pharmacology gamma-Aminobutyric Acid - physiology Hippocampus - drug effects Hippocampus - physiology Hippocampus - physiopathology Inhibitory Postsynaptic Potentials Isoxazoles - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Neural Inhibition Neurons - drug effects Neurons - physiology Seizures - physiopathology Synapsins - genetics Synapsins - physiology
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