Follow-Up of Infants Diagnosed with HIV — Early Infant Diagnosis Program, Francistown, Botswana, 2005–2012
The 2011 prevalence of human immunodeficiency virus (HIV) among pregnant women in Botswana was 30.4%. High coverage rates of HIV testing and antiretroviral prophylaxis have reduced the rate of mother-to-child transmission of HIV in Botswana from as high as 40% with no prophylaxis to
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| Veröffentlicht in: | MMWR. Morbidity and mortality weekly report 2014-02, Vol.63 (7), p.158-160 |
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| creator | Motswere-Chirwa, Catherine Voetsch, Andrew Lu, Lydia Letsholathebe, Victor Lekone, Phenyo Machakaire, Esther Legwaila, Keitumetse Matambo, Stembile Maruping, Maruping Kolobe, Thatayotlhe Petlo, Chipo Lebelonyane, Refeletswe Glenshaw, Mary Dale, Helen Davis, Margarett Halabi, Shenaaz El Pelletier, Andrew |
| description | The 2011 prevalence of human immunodeficiency virus (HIV) among pregnant women in Botswana was 30.4%. High coverage rates of HIV testing and antiretroviral prophylaxis have reduced the rate of mother-to-child transmission of HIV in Botswana from as high as 40% with no prophylaxis to |
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High coverage rates of HIV testing and antiretroviral prophylaxis have reduced the rate of mother-to-child transmission of HIV in Botswana from as high as 40% with no prophylaxis to <4% in 2011. In June 2005, the national Early Infant Diagnosis (EID) Program began testing HIV-exposed infants (i.e., those born to HIV-infected mothers) for HIV using polymerase chain reaction (PCR) at 6 weeks postpartum. During 2005-2012, follow-up of all HIV-infected infants diagnosed in all 13 postnatal care facilities in Francistown, Botswana, was conducted to ascertain patient outcomes. A total of 202 infants were diagnosed with HIV. As of September 2013, 82 (41%) children were alive and on antiretroviral therapy (ART), 79 (39%) had died, and 41 (20%) were either lost to follow-up, had transferred, or their mothers declined ART. Despite success in preventing mother-to-child transmission in Botswana, results of the EID program highlight the need for early diagnosis of HIV-infected infants, prompt initiation of ART, and retention in care.</description><identifier>ISSN: 0149-2195</identifier><identifier>EISSN: 1545-861X</identifier><identifier>PMID: 24553200</identifier><language>eng</language><publisher>United States: Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</publisher><subject>African art ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretrovirals ; Antiviral agents ; Art therapy ; Assisted reproductive techniques ; Babies ; Botswana ; Counseling - statistics & numerical data ; Disease prevention ; Disease transmission ; Early diagnosis ; Female ; Follow-Up Studies ; Health outcomes ; HIV ; HIV (Viruses) ; HIV infections ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; HIV Infections - mortality ; HIV Infections - transmission ; HIV patients ; HIV testing ; Human immunodeficiency virus ; Humans ; Infant ; Infants ; Infectious Disease Transmission, Vertical - prevention & control ; Male ; Mortality ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications, Infectious - prevention & control ; Pregnant women ; Program Evaluation ; Survival Rate ; Treatment Outcome</subject><ispartof>MMWR. Morbidity and mortality weekly report, 2014-02, Vol.63 (7), p.158-160</ispartof><rights>COPYRIGHT 2014 U.S. Government Printing Office</rights><rights>Copyright U.S. Center for Disease Control Feb 21, 2014</rights><rights>2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24854914$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24854914$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24553200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motswere-Chirwa, Catherine</creatorcontrib><creatorcontrib>Voetsch, Andrew</creatorcontrib><creatorcontrib>Lu, Lydia</creatorcontrib><creatorcontrib>Letsholathebe, Victor</creatorcontrib><creatorcontrib>Lekone, Phenyo</creatorcontrib><creatorcontrib>Machakaire, Esther</creatorcontrib><creatorcontrib>Legwaila, Keitumetse</creatorcontrib><creatorcontrib>Matambo, Stembile</creatorcontrib><creatorcontrib>Maruping, Maruping</creatorcontrib><creatorcontrib>Kolobe, Thatayotlhe</creatorcontrib><creatorcontrib>Petlo, Chipo</creatorcontrib><creatorcontrib>Lebelonyane, Refeletswe</creatorcontrib><creatorcontrib>Glenshaw, Mary</creatorcontrib><creatorcontrib>Dale, Helen</creatorcontrib><creatorcontrib>Davis, Margarett</creatorcontrib><creatorcontrib>Halabi, Shenaaz El</creatorcontrib><creatorcontrib>Pelletier, Andrew</creatorcontrib><creatorcontrib>Centers for Disease Control and Prevention (CDC)</creatorcontrib><title>Follow-Up of Infants Diagnosed with HIV — Early Infant Diagnosis Program, Francistown, Botswana, 2005–2012</title><title>MMWR. Morbidity and mortality weekly report</title><addtitle>MMWR Morb Mortal Wkly Rep</addtitle><description>The 2011 prevalence of human immunodeficiency virus (HIV) among pregnant women in Botswana was 30.4%. High coverage rates of HIV testing and antiretroviral prophylaxis have reduced the rate of mother-to-child transmission of HIV in Botswana from as high as 40% with no prophylaxis to <4% in 2011. In June 2005, the national Early Infant Diagnosis (EID) Program began testing HIV-exposed infants (i.e., those born to HIV-infected mothers) for HIV using polymerase chain reaction (PCR) at 6 weeks postpartum. During 2005-2012, follow-up of all HIV-infected infants diagnosed in all 13 postnatal care facilities in Francistown, Botswana, was conducted to ascertain patient outcomes. A total of 202 infants were diagnosed with HIV. As of September 2013, 82 (41%) children were alive and on antiretroviral therapy (ART), 79 (39%) had died, and 41 (20%) were either lost to follow-up, had transferred, or their mothers declined ART. Despite success in preventing mother-to-child transmission in Botswana, results of the EID program highlight the need for early diagnosis of HIV-infected infants, prompt initiation of ART, and retention in care.</description><subject>African art</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretrovirals</subject><subject>Antiviral agents</subject><subject>Art therapy</subject><subject>Assisted reproductive techniques</subject><subject>Babies</subject><subject>Botswana</subject><subject>Counseling - statistics & numerical data</subject><subject>Disease prevention</subject><subject>Disease transmission</subject><subject>Early diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health outcomes</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV infections</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - mortality</subject><subject>HIV Infections - transmission</subject><subject>HIV patients</subject><subject>HIV testing</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Male</subject><subject>Mortality</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - prevention & control</subject><subject>Pregnant women</subject><subject>Program Evaluation</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0149-2195</issn><issn>1545-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0s1uEzEQAOAVAtFQeASQBRLikEX-3Z8LUikNjVQJDhRxs2Z3vRtXXju1HaLe-g7whH0SXJKiBMU-WPJ8nrHGfpRNiOAirwry43E2wYTXOSW1OMqehXCF7wfDT7MjyoVgFONJZmfOGLfOL5fI9Whue7AxoE8aBuuC6tBaxwU6n39Hd7e_0Rl4c7NFD0YH9NW7wcM4RTMPttUhurWdoo8uhjVYmKJUSNzd_qKY0OfZkx5MUC-263F2OTv7dnqeX3z5PD89ucgHLkjMC9w0BQPWk6bCpCmLjtIWiCh70YJqscBdqwhtMasbXFVNiSljtGS87ztQJbDj7MMm73LVjCphGz0YufR6BH8jHWi5H7F6IQf3U3JR8bIgKcHrbQLvrlcqROnV0vkYJBGYUU5qXCf07j806tAqY8Aqt_pLCSvLitBE32zoAEZJbXuXyrb3XJ6wglaCiYInlR9Qg7Iq3dFZ1eu0veffH_BpdmrU7cEDb3cOLBSYuAjOrKJ2NuzDV7sN_Ne5h5-TwMsNuErv7XfileA14ewPioHHTg</recordid><startdate>20140221</startdate><enddate>20140221</enddate><creator>Motswere-Chirwa, Catherine</creator><creator>Voetsch, Andrew</creator><creator>Lu, Lydia</creator><creator>Letsholathebe, Victor</creator><creator>Lekone, Phenyo</creator><creator>Machakaire, Esther</creator><creator>Legwaila, Keitumetse</creator><creator>Matambo, Stembile</creator><creator>Maruping, Maruping</creator><creator>Kolobe, Thatayotlhe</creator><creator>Petlo, Chipo</creator><creator>Lebelonyane, Refeletswe</creator><creator>Glenshaw, Mary</creator><creator>Dale, Helen</creator><creator>Davis, Margarett</creator><creator>Halabi, Shenaaz El</creator><creator>Pelletier, Andrew</creator><general>Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</general><general>U.S. Government Printing Office</general><general>U.S. Center for Disease Control</general><general>U.S. Centers for Disease Control</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88F</scope><scope>88J</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M1Q</scope><scope>M2O</scope><scope>M2R</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20140221</creationdate><title>Follow-Up of Infants Diagnosed with HIV — Early Infant Diagnosis Program, Francistown, Botswana, 2005–2012</title><author>Motswere-Chirwa, Catherine ; Voetsch, Andrew ; Lu, Lydia ; Letsholathebe, Victor ; Lekone, Phenyo ; Machakaire, Esther ; Legwaila, Keitumetse ; Matambo, Stembile ; Maruping, Maruping ; Kolobe, Thatayotlhe ; Petlo, Chipo ; Lebelonyane, Refeletswe ; Glenshaw, Mary ; Dale, Helen ; Davis, Margarett ; Halabi, Shenaaz El ; Pelletier, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g451t-60bb63a3f1b801b76d22ca157f5caec050dce12c039b088b702332734ffdae7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>African art</topic><topic>Anti-HIV Agents - 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A total of 202 infants were diagnosed with HIV. As of September 2013, 82 (41%) children were alive and on antiretroviral therapy (ART), 79 (39%) had died, and 41 (20%) were either lost to follow-up, had transferred, or their mothers declined ART. Despite success in preventing mother-to-child transmission in Botswana, results of the EID program highlight the need for early diagnosis of HIV-infected infants, prompt initiation of ART, and retention in care.</abstract><cop>United States</cop><pub>Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</pub><pmid>24553200</pmid><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | MMWR. Morbidity and mortality weekly report, 2014-02, Vol.63 (7), p.158-160 |
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| source | MEDLINE; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | African art Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretrovirals Antiviral agents Art therapy Assisted reproductive techniques Babies Botswana Counseling - statistics & numerical data Disease prevention Disease transmission Early diagnosis Female Follow-Up Studies Health outcomes HIV HIV (Viruses) HIV infections HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - mortality HIV Infections - transmission HIV patients HIV testing Human immunodeficiency virus Humans Infant Infants Infectious Disease Transmission, Vertical - prevention & control Male Mortality Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious - prevention & control Pregnant women Program Evaluation Survival Rate Treatment Outcome |
| title | Follow-Up of Infants Diagnosed with HIV — Early Infant Diagnosis Program, Francistown, Botswana, 2005–2012 |
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