Engineered composite fascia for stem cell therapy in tissue repair applications

[Display omitted] A critical challenge in tissue regeneration is to develop constructs that effectively integrate with the host tissue. Here, we describe a composite, laser micromachined, collagen–alginate construct containing human mesenchymal stem cells (hMSCs) for tissue repair applications. Coll...

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Veröffentlicht in:	Acta biomaterialia 2015-10, Vol.26, p.1-12
Hauptverfasser:	Ayala, Perla, Caves, Jeffrey, Dai, Erbin, Siraj, Layla, Liu, Liying, Chaudhuri, Ovijit, Haller, Carolyn A., Mooney, David J., Chaikof, Elliot L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate Alginates - chemistry Animals Biomimetic Materials - chemical synthesis Collagen Collagen - chemistry Construction Defects Equipment Design Equipment Failure Analysis Fascia - chemistry Fascia - transplantation Female Full thickness abdominal defect Glucuronic Acid - chemistry Guided Tissue Regeneration - instrumentation Guided Tissue Regeneration - methods Hernia - pathology Hernia - therapy Herniorrhaphy - instrumentation Herniorrhaphy - methods Hexuronic Acids - chemistry Human mesenchymal stem cells Humans Immune response Integration Lasers Macrophages Mesenchymal Stem Cell Transplantation - instrumentation Micromachining Micromechanics Rats Rats, Wistar Repair Strength Tissue Engineering - instrumentation Tissue repair Tissue Scaffolds Treatment Outcome Vascularization
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