Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have d...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-22 |
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| description | The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed. |
| doi_str_mv | 10.1155/2015/476508 |
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However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/476508</identifier><identifier>PMID: 26448938</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Angiogenesis ; Biomedical research ; Cancer ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - genetics ; Cell growth ; Chromosome Aberrations ; Chromosomes ; Colleges & universities ; Gene expression ; Genetic aspects ; Genetic Markers - genetics ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Growth factors ; Histology ; Humans ; Kidney cancer ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - genetics ; Medical prognosis ; Medical research ; Mutation ; Mutation - genetics ; Observations ; Polymorphism, Single Nucleotide - genetics ; Prevalence ; Prognosis ; Proteins ; Review ; Risk Assessment - methods ; Risk Factors ; Tumors</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-22</ispartof><rights>Copyright © 2015 Ning Yi Yap et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Ning Yi Yap et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Ning Yi Yap et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-1f7691b8e0f4f1505e048b3b21a47fb2d83e47a0a87c735eaea558fb3843b86c3</citedby><cites>FETCH-LOGICAL-c528t-1f7691b8e0f4f1505e048b3b21a47fb2d83e47a0a87c735eaea558fb3843b86c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584050/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584050/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26448938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arnaoutakis, Konstantinos</contributor><creatorcontrib>Fadzli, Ahmad</creatorcontrib><creatorcontrib>Pailoor, Jayalakshmi</creatorcontrib><creatorcontrib>Ng, Keng Lim</creatorcontrib><creatorcontrib>Rajandram, Retnagowri</creatorcontrib><creatorcontrib>Yap, Ning Yi</creatorcontrib><creatorcontrib>Gobe, Glenda C.</creatorcontrib><title>Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.</description><subject>Angiogenesis</subject><subject>Biomedical research</subject><subject>Cancer</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Cell growth</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes</subject><subject>Colleges & universities</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Growth factors</subject><subject>Histology</subject><subject>Humans</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Observations</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Review</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks9rFDEUx4MottSevMuAF6mszcuvyV6EZdG2UBS0eg2Z7MtuykyyJrOK_70Zt67VU3PJI98PX17e-xLyHOgbACnPGQV5LlolqX5EjhkHMVMg4PGh5vyInJZyS-vRoOhcPSVHTAmh51wfk68XGHEMrrFx1Sw3OQ2ppMH2zaLDnO0YUiy_tZsNhtws-xCDq_LnsI7B1zI6bEJsPmGsrx8wbXtbhvKMPPG2L3h6d5-QL-_f3SwvZ9cfL66Wi-uZk0yPM_CtmkOnkXrhQVKJVOiOdwysaH3HVpqjaC21unUtl2jRSql9x7XgnVaOn5C3e9_trhtw5TCO2fZmm8Ng80-TbDD_KjFszDp9N0JqQSWtBq_uDHL6tsMymiEUh31vI6ZdMdAyBi2HuXgIClxywSfXl_-ht2mX64QmCpTWSlH1l1rbHk2IPtUW3WRqFrU_UNO6KvV6T7mcSsnoD78DaqYMmCkDZp-BSr-4P5AD-2fjFTjbA5sQV_ZHeJgbVgS9vQdLqRjnvwCOTsBq</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Fadzli, Ahmad</creator><creator>Pailoor, Jayalakshmi</creator><creator>Ng, Keng Lim</creator><creator>Rajandram, Retnagowri</creator><creator>Yap, Ning Yi</creator><creator>Gobe, Glenda C.</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms</title><author>Fadzli, Ahmad ; Pailoor, Jayalakshmi ; Ng, Keng Lim ; Rajandram, Retnagowri ; Yap, Ning Yi ; Gobe, Glenda C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-1f7691b8e0f4f1505e048b3b21a47fb2d83e47a0a87c735eaea558fb3843b86c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Angiogenesis</topic><topic>Biomedical research</topic><topic>Cancer</topic><topic>Carcinoma, Renal Cell - 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| subjects | Angiogenesis Biomedical research Cancer Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - genetics Cell growth Chromosome Aberrations Chromosomes Colleges & universities Gene expression Genetic aspects Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Growth factors Histology Humans Kidney cancer Kidney Neoplasms - epidemiology Kidney Neoplasms - genetics Medical prognosis Medical research Mutation Mutation - genetics Observations Polymorphism, Single Nucleotide - genetics Prevalence Prognosis Proteins Review Risk Assessment - methods Risk Factors Tumors |
| title | Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
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