CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and includes a PAX3- or PAX7-FOXO1 fusion-positive subtype. Amplification of chromosomal region 12q13-q14, which contains the CDK4 proto-oncogene, was identified in an aggressive subset of fusion-positive RMS. CDK4/6 inhibitors...

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Veröffentlicht in:	Clinical cancer research 2015-11, Vol.21 (21), p.4947-4959
Hauptverfasser:	Olanich, Mary E, Sun, Wenyue, Hewitt, Stephen M, Abdullaev, Zied, Pack, Svetlana D, Barr, Frederic G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Chromosomes, Human, Pair 12 Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 6 - antagonists & inhibitors Disease Models, Animal Drug Resistance, Neoplasm - genetics E2F Transcription Factors - metabolism Female G1 Phase Cell Cycle Checkpoints - genetics Gene Amplification Gene Deletion Gene Expression Gene Knockdown Techniques Humans Mice Oncogene Proteins, Fusion - genetics Protein Kinase Inhibitors - pharmacology Retinoblastoma Protein - metabolism Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - genetics Rhabdomyosarcoma - pathology RNA Interference Tumor Burden - drug effects Tumor Burden - genetics Xenograft Model Antitumor Assays
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