Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

BACKGROUNDFlavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom-containing drugs and xenobiotics, including nicotine. Rare mutations in FMO3 are responsible for defective N-oxidation of dietary trimethylamine leading to trimethylaminuria, and common genetic variat...

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Veröffentlicht in:	Pharmacogenetics and genomics 2013-02, Vol.23 (2), p.62-68
Hauptverfasser:	Bloom, A Joseph, Murphy, Sharon E, Martinez, Maribel, von Weymarn, Linda B, Bierut, Laura J, Goate, Alison
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chromatography, Liquid Cotinine - metabolism European Continental Ancestry Group Female Genotype Haplotypes - genetics Humans Male Metabolic Clearance Rate Nicotine - metabolism Oxygenases - genetics Polymorphism, Genetic - genetics Tandem Mass Spectrometry Tobacco Products
Online-Zugang:	Volltext
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