Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-specific growth factors with central roles in mammalian reproduction, regulating species-specific fecundity, ovarian follicular somatic cell differentiation, and oocyte quality. In the human, GDF9 is produced...

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Veröffentlicht in:	The Journal of biological chemistry 2015-09, Vol.290 (39), p.24007-24020
Hauptverfasser:	Mottershead, David G., Sugimura, Satoshi, Al-Musawi, Sara L., Li, Jing-Jie, Richani, Dulama, White, Melissa A., Martin, Georgia A., Trotta, Andrew P., Ritter, Lesley J., Shi, Junyan, Mueller, Thomas D., Harrison, Craig A., Gilchrist, Robert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone morphogenetic protein (BMP) Bone Morphogenetic Protein 15 - genetics Bone Morphogenetic Protein 15 - metabolism cumulin cumulus granulosa cell Developmental Biology Female Granulosa Cells - cytology Granulosa Cells - metabolism growth differentiation factor Growth Differentiation Factor 9 - genetics Growth Differentiation Factor 9 - metabolism Humans IVM Mice oocyte quality Oocytes - cytology Oocytes - metabolism protein assembly Protein Multimerization - physiology protein secretion Signal Transduction - physiology Smad Proteins - genetics Smad Proteins - metabolism SMAD transcription factor transforming growth factor beta (TGF-β)
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