Interleukin‐17A deficiency ameliorates streptozotocin‐induced diabetes

Summary Interleukin‐17 (IL‐17) is a cytokine with critical functions in multiple autoimmune diseases. However, its roles in type I diabetes and the underlying mechanisms remain to be fully elucidated. In the current study, we investigated the impact of IL‐17 deficiency on streptozotocin (STZ) ‐induc...

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Veröffentlicht in:	Immunology 2015-10, Vol.146 (2), p.339-346
Hauptverfasser:	Tong, Zan, Liu, Weihuang, Yan, Huichao, Dong, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Biomarkers - blood Blood Glucose - metabolism CD11b Antigen - immunology CD11b Antigen - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Cells, Cultured Chemotaxis, Leukocyte Coculture Techniques diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - prevention & control Insulin - blood Interleukin-17 - deficiency Interleukin-17 - genetics interleukin‐17A Lymphocyte Activation Mice, Inbred C57BL Mice, Knockout Myeloid Cells - immunology Myeloid Cells - metabolism Myeloid Cells - transplantation myeloid‐derived suppressor cells Original Pancreas - immunology Pancreas - metabolism Pancreas - pathology Receptors, Chemokine - immunology Receptors, Chemokine - metabolism Spleen - immunology Spleen - metabolism streptozotocin Time Factors
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