Structural and functional hepatocyte polarity and liver disease

Summary Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver sinusoidal endothelial cells, while one or more apical poles can contribute to several bile canaliculi joint...

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Veröffentlicht in:	Journal of hepatology 2015-10, Vol.63 (4), p.1023-1037
Hauptverfasser:	Gissen, Paul, Arias, Irwin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Canalicular diseases Cholestasis Gastroenterology and Hepatology Hepatocyte biology Hepatocyte polarity Hepatocytes - metabolism Hepatocytes - pathology Humans Inherited liver diseases Liver Diseases - genetics Liver Diseases - metabolism Liver Diseases - pathology Phenotype Review Tight Junctions
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