Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β

Objective Systemic sclerosis (SSc) is characterized by severe and often progressive fibrosis of the skin and multiple internal organs. The mechanisms responsible for these alterations remain obscure, although excessive reactive oxygen species (ROS)–mediated oxidative stress has been implicated. NOX‐...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2015-10, Vol.67 (10), p.2749-2758
Hauptverfasser:	Piera‐Velazquez, Sonsoles, Makul, Alma, Jiménez, Sergio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Cells, Cultured Collagen - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fibronectins - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans Hydrogen Peroxide - metabolism NADPH Oxidase 4 NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress - drug effects Protein Kinase C-delta - metabolism Reactive Oxygen Species - metabolism RNA, Small Interfering - pharmacology Signal Transduction - drug effects Skin - cytology Skin - drug effects Skin - metabolism Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology
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