A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms

Human esophageal cancer-related gene 4 (ECRG4) is a potential tumor suppressor gene isolated from human esophageal epithelial cells. Studies have shown that ECRG4 effectively inhibits the proliferation of tumor cells and induces apoptosis. However, the role of ECRG4 in laryngeal cancer has not yet b...

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Veröffentlicht in:	Molecular medicine reports 2015-10, Vol.12 (4), p.5058-5064
Hauptverfasser:	JIA, JIANPING, DAI, SONG, SUN, XINGHE, SANG, YUEHONG, XU, ZHENMING, ZHANG, JIE, CUI, XIAOFENG, SONG, JINHUI, GUO, XING
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics B-cell lymphoma Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biotechnology Cancer therapies Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Cell cycle Cell Line, Tumor Cell Proliferation Cytochrome Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Esophageal cancer Esophagus Flow cytometry Founder Effect G1 phase G1 Phase Cell Cycle Checkpoints - genetics Gene expression Gene Expression Regulation, Neoplastic Gene therapy Hep-2 cells human esophageal cancer-related gene 4 Humans Immunofluorescence Laryngeal cancer Laryngeal carcinoma Larynx - metabolism Larynx - pathology Lymphocytes B Membranes Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Overexpression Plasmids - chemistry Plasmids - metabolism Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Polyclonal antibodies Polymerase chain reaction proliferation Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse transcription Ribose Signal Transduction Studies Thermal cycling Transfection Tumor cells Tumor suppressor genes
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