Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals

Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals

DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within sh...

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Veröffentlicht in:Human molecular genetics 2015-10, Vol.24 (20), p.5733-5745
Hauptverfasser: Shin, Jean, Bourdon, Celine, Bernard, Manon, Wilson, Michael D, Reischl, Eva, Waldenberger, Melanie, Ruggeri, Barbara, Schumann, Gunter, Desrivieres, Sylvane, Leemans, Alexander, Abrahamowicz, Michal, Leonard, Gabriel, Richer, Louis, Bouchard, Luigi, Gaudet, Daniel, Paus, Tomas, Pausova, Zdenka
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Alleles
Chromosomes, Human, Pair 6
CpG Islands
DNA Methylation
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Genomics
Humans
Linkage Disequilibrium
Male
Middle Aged
Multiple Sclerosis - genetics
Quantitative Trait Loci
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Zusammenfassung:DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within short genomic regions (
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddv294