Development of a New Monomer for the Synthesis of Intrinsic Antimicrobial Polymers with Enhanced Material Properties

The use of biocidal compounds in polymers is steadily increasing because it is one solution to the need for safety and hygiene. It is possible to incorporate an antimicrobial moiety to a polymer. These polymers are referred to as intrinsic antimicrobial. The biocidal action results from contact of t...

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Veröffentlicht in:International journal of molecular sciences 2015-08, Vol.16 (8), p.20050-20066
Hauptverfasser: Brodkorb, Florian, Fischer, Björn, Kalbfleisch, Katrin, Robers, Oliver, Braun, Carina, Dohlen, Sophia, Kreyenschmidt, Judith, Lorenz, Reinhard, Kreyenschmidt, Martin
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container_end_page 20066
container_issue 8
container_start_page 20050
container_title International journal of molecular sciences
container_volume 16
creator Brodkorb, Florian
Fischer, Björn
Kalbfleisch, Katrin
Robers, Oliver
Braun, Carina
Dohlen, Sophia
Kreyenschmidt, Judith
Lorenz, Reinhard
Kreyenschmidt, Martin
description The use of biocidal compounds in polymers is steadily increasing because it is one solution to the need for safety and hygiene. It is possible to incorporate an antimicrobial moiety to a polymer. These polymers are referred to as intrinsic antimicrobial. The biocidal action results from contact of the polymer to the microorganisms, with no release of active molecules. This is particularly important in critical fields like food technology, medicine and ventilation technology, where migration or leaching is crucial and undesirable. The isomers N-(1,1-dimethylethyl)-4-ethenyl-benzenamine and N-(1,1-dimethyl-ethyl)-3-ethenyl-benzenamine (TBAMS) are novel (Co-)Monomers for intrinsic anti-microbial polymers. The secondary amines were prepared and polymerized to the corresponding water insoluble polymer. The antimicrobial activity was analyzed by the test method JIS Z 2801:2000. Investigations revealed a high antimicrobial activity against Staphylococcus aureus and Escherichia coli with a reduction level of >4.5 log10 units. Furthermore, scanning electron microscopy (SEM) of E. coli. in contact with the polymer indicates a bactericidal action which is caused by disruption of the bacteria cell membranes, leading to lysis of the cells.
doi_str_mv 10.3390/ijms160820050
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source MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Cell Membrane - drug effects
Escherichia coli
Escherichia coli - drug effects
Microbial Sensitivity Tests
Polymers
Polymers - chemistry
Protein synthesis
Staphylococcus aureus
Staphylococcus aureus - drug effects
title Development of a New Monomer for the Synthesis of Intrinsic Antimicrobial Polymers with Enhanced Material Properties
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