Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of HIV-1-infected cells in individuals treated with suppressive combination antiretroviral therapy (cART). However, the effects of such latency...

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Veröffentlicht in:	Journal of virology 2015-10, Vol.89 (20), p.10176-10189
Hauptverfasser:	Olesen, Rikke, Vigano, Selena, Rasmussen, Thomas A, Søgaard, Ole S, Ouyang, Zhengyu, Buzon, Maria, Bashirova, Arman, Carrington, Mary, Palmer, Sarah, Brinkmann, Christel R, Yu, Xu G, Østergaard, Lars, Tolstrup, Martin, Lichterfeld, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Antigens, CD - immunology Antiretroviral Therapy, Highly Active CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cell Count Dendritic Cells - drug effects Dendritic Cells - enzymology Dendritic Cells - immunology Dendritic Cells - virology DNA, Viral - antagonists & inhibitors DNA, Viral - genetics DNA, Viral - immunology Drug Administration Schedule Gene Expression Genotype Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - genetics Histone Deacetylases - immunology HIV Infections - drug therapy HIV Infections - enzymology HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - growth & development HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Hydroxamic Acids - therapeutic use Immunity, Innate - drug effects Indoles - therapeutic use Interferons Interleukins - genetics Interleukins - immunology Killer Cells, Natural - drug effects Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Killer Cells, Natural - virology Panobinostat Pathogenesis and Immunity Virus Latency - drug effects
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