Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine

Live attenuated recombinant human parainfluenza virus type 1 (rHPIV1) was investigated as a vector to express the respiratory syncytial virus (RSV) fusion (F) glycoprotein, to provide a bivalent vaccine against RSV and HPIV1. The RSV F gene was engineered to include HPIV1 transcription signals and i...

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Veröffentlicht in:	Journal of virology 2015-10, Vol.89 (20), p.10319-10332
Hauptverfasser:	Mackow, Natalie, Amaro-Carambot, Emérito, Liang, Bo, Surman, Sonja, Lingemann, Matthias, Yang, Lijuan, Collins, Peter L, Munir, Shirin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Base Sequence Cricetulus Genetic Vectors - chemistry Genetic Vectors - metabolism Human respiratory syncytial virus Humans Molecular Sequence Data Parainfluenza virus Parainfluenza Virus 1, Human - genetics Parainfluenza Virus 1, Human - immunology Paramyxoviridae Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - immunology Respirovirus Infections - immunology Respirovirus Infections - prevention & control Respirovirus Infections - virology Sequence Deletion Vaccination Vaccines and Antiviral Agents Vaccines, Attenuated Vaccines, Synthetic Viral Fusion Proteins - genetics Viral Fusion Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Virus Replication
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