Blood pressure, sex, and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in spontaneously hypertensive rats

We previously reported that sexually mature female spontaneously hypertensive rats (SHRs) have greater nitric oxide (NO) synthase (NOS) enzymatic activity in the renal inner medulla (IM), compared to age-matched males. However, the mechanisms responsible for this sexual dimorphism are unknown. The c...

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Veröffentlicht in:	Journal of the American Heart Association 2015-04, Vol.4 (4)
Hauptverfasser:	Sasser, Jennifer M, Brinson, Krystal N, Tipton, Ashlee J, Crislip, G Ryan, Sullivan, Jennifer C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Antihypertensive Agents - pharmacology Blood Pressure - physiology Female Hydrochlorothiazide - pharmacology Kidney Medulla - drug effects Kidney Medulla - enzymology Kidney Medulla - metabolism Male Nitric Oxide Synthase - analysis Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Original Research Ovariectomy Rats Rats, Inbred SHR - metabolism Rats, Inbred SHR - physiology Reserpine - pharmacology Sex Factors Sexual Maturation - physiology
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