Effect of phosphorylation and methylation on the function of the p16INK4a protein in non-small cell lung cancer A549 cells

The p16INK4a protein (p16) has been reported to be a tumor suppressor gene that suppresses the proliferation of cells through the direct inhibition of cell cycle progression. Accordingly, p16 is a potential target for cancer gene therapy. In the present study, the arginine 22, 131 and 138 residues o...

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