Class I histone deacetylases localize to the endoplasmic reticulum and modulate the unfolded protein response

Post‐translational modification through protein acetylation is emerging as an important mode of cellular regulation. We have previously demonstrated the role that glucose‐regulated protein 78 kDa (GRP78) acetylation and subsequent activation of the unfolded protein response (UPR) play in the antitum...

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Veröffentlicht in:	The FASEB journal 2012-06, Vol.26 (6), p.2437-2445
Hauptverfasser:	Kahali, Soumen, Sarcar, Bhaswati, Prabhu, Antony, Seto, Edward, Chinnaiyan, Prakash
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Cell Line, Tumor Endoplasmic Reticulum - metabolism GRP78 HDAC inhibitor Heat-Shock Proteins - metabolism Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Humans Research Communications RNA Interference Unfolded Protein Response - drug effects
Online-Zugang:	Volltext
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