The key roles of complement and tissue factor in Escherichia coli‐induced coagulation in human whole blood

Summary The complement system and the Toll‐like (TLR) co‐receptor CD14 play important roles in innate immunity and sepsis. Tissue factor (TF) is a key initiating component in intravascular coagulation in sepsis, and long pentraxin 3 (PTX3) enhances the lipopolysaccharide (LPS)‐induced transcription...

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Veröffentlicht in:	Clinical and experimental immunology 2015-10, Vol.182 (1), p.81-89
Hauptverfasser:	Landsem, A., Fure, H., Christiansen, D., Nielsen, E. W., Østerud, B., Mollnes, T. E., Brekke, O. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombins - pharmacology Blood Coagulation - immunology C-Reactive Protein - immunology CD14 coagulation complement Complement C3 - antagonists & inhibitors Complement C3 - immunology Escherichia coli Escherichia coli - immunology Hirudins - pharmacology Humans lipopolysaccharide Lipopolysaccharide Receptors - immunology Lipopolysaccharide Receptors - metabolism Lipopolysaccharides Original Peptide Fragments - immunology Peptides, Cyclic - pharmacology Prothrombin - immunology Recombinant Proteins - pharmacology RNA, Messenger - genetics sepsis Sepsis - immunology Sepsis - microbiology Serum Amyloid P-Component - immunology Thromboplastin - biosynthesis Thromboplastin - genetics Thromboplastin - immunology Up-Regulation whole blood
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