Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice

Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to prospectively evaluate this dosing regimen. First, early (before and after second dose) therapeutic drug monitoring (TDM) observations were eval...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-10, Vol.59 (10), p.6344-6351
Hauptverfasser:	Smits, A, De Cock, R F W, Allegaert, K, Vanhaesebrouck, S, Danhof, M, Knibbe, C A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin Amikacin - blood Amikacin - pharmacokinetics Amikacin - pharmacology Anti-Bacterial Agents Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Birth Weight Creatinine - blood Dose-Response Relationship, Drug Drug Administration Schedule Drug Monitoring Female Gestational Age Humans Infant Infant, Newborn Infant, Premature Male Models, Statistical Monte Carlo Method Pharmacology Precision Medicine Prospective Studies Sepsis - drug therapy Sepsis - microbiology Sepsis - pathology
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