Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases

Sugar aminotransferases (SATs) are an important class of tailoring enzymes that catalyze the 5′-pyridoxal phosphate (PLP)-dependent stereo- and regiospecific installation of an amino group from an amino acid donor (typically l-Glu or l-Gln) to a corresponding ketosugar nucleotide acceptor. Herein we...

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Veröffentlicht in:	ACS chemical biology 2015-09, Vol.10 (9), p.2048-2056
Hauptverfasser:	Wang, Fengbin, Singh, Shanteri, Xu, Weijun, Helmich, Kate E, Miller, Mitchell D, Cao, Hongnan, Bingman, Craig A, Thorson, Jon S, Phillips, George N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Amines - chemistry Amines - metabolism Amino Acids - chemistry Amino Acids - metabolism BASIC BIOLOGICAL SCIENCES Binding Sites Carbohydrates Catalytic Domain Chemical structure Crystallography, X-Ray Escherichia coli - chemistry Escherichia coli - enzymology Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Micromonospora - chemistry Micromonospora - enzymology Micromonospora - metabolism Models, Molecular Monomers Nucleotides - chemistry Nucleotides - metabolism Peptides and proteins Protein Conformation Pyridoxal Phosphate - metabolism Substrate Specificity Transaminases - chemistry Transaminases - metabolism
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