Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease
OBJECTIVE To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. DESIGN A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise. SETTING T...
Gespeichert in:
| Veröffentlicht in: | Archives of neurology (Chicago) 2013-02, Vol.70 (2), p.1-8 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8 |
|---|---|
| container_issue | 2 |
| container_start_page | 1 |
| container_title | Archives of neurology (Chicago) |
| container_volume | 70 |
| creator | Shulman, Lisa M Katzel, Leslie I Ivey, Frederick M Sorkin, John D Favors, Knachelle Anderson, Karen E Smith, Barbara A Reich, Stephen G Weiner, William J Macko, Richard F |
| description | OBJECTIVE To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. DESIGN A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise. SETTING The Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center. PATIENTS A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months. MAIN OUTCOME MEASURES The primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [[Vdot]O2], and muscle strength (1-repetition maximum strength). RESULTS All 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P = .001), stretching and resistance exercises (9% increase; P |
| doi_str_mv | 10.1001/jamaneurol.2013.646 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4574905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>1389386</ama_id><sourcerecordid>1291607906</sourcerecordid><originalsourceid>FETCH-LOGICAL-a424t-7ba2056e8752c145ce2d67ce7cc8a83f69f8608267bf423d76dea67bd3d8efcd3</originalsourceid><addsrcrecordid>eNpVkVtPGzEQhS1UBOHyB1oJ7SMvG3xb2_uCVAVoKyGBqiCekOXYs43p7jrYG0T663EIt77YM5pzjkf-EPpG8JhgTE7uTWd6WMbQjikmbCy42EIjUjFVMqHkFzTCGLOyrjndRXsp3WcTVareQbuU5YpTOUJ3v03vQuf_gSsmre-9NW0xjT6foSlYMV0tIK3L6_kqvQzPnyBan6BoQiyuzeChH1Jx64d57uJf36fQF2dZYBIcoO3GtAkOX-99dHNxPp38LC-vfvyafL8sDad8KOXMUFwJULKilvDKAnVCWpDWKqNYI-pGCayokLOGU-akcGBy45hT0FjH9tHpJnexnHXgbF4pmlYvou9MXOlgvP5_0vu5_hMeNa8kr3GVA45fA2J4WEIadOeThbbNPxyWSRNaE4FljUWWso3UxpBShOb9GYL1Goz-AKPXYHQGk11Hnzd897yRyIKvG0E2fyQyVTMl2DNaVJbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1291607906</pqid></control><display><type>article</type><title>Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Shulman, Lisa M ; Katzel, Leslie I ; Ivey, Frederick M ; Sorkin, John D ; Favors, Knachelle ; Anderson, Karen E ; Smith, Barbara A ; Reich, Stephen G ; Weiner, William J ; Macko, Richard F</creator><creatorcontrib>Shulman, Lisa M ; Katzel, Leslie I ; Ivey, Frederick M ; Sorkin, John D ; Favors, Knachelle ; Anderson, Karen E ; Smith, Barbara A ; Reich, Stephen G ; Weiner, William J ; Macko, Richard F</creatorcontrib><description>OBJECTIVE To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. DESIGN A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise. SETTING The Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center. PATIENTS A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months. MAIN OUTCOME MEASURES The primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [[Vdot]O2], and muscle strength (1-repetition maximum strength). RESULTS All 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P = .001), stretching and resistance exercises (9% increase; P < .02), and higher-intensity treadmill exercise (6% increase; P = .07), with no between-group differences. Both treadmill exercises improved peak [Vdot]O2 (7%-8% increase; P < .05) more than did the stretching and resistance exercises. Only stretching and resistance improved muscle strength (16% increase; P < .001). CONCLUSIONS The effects of exercise were seen across all 3 exercise groups. The lower-intensity treadmill exercise resulted in the greatest improvement in gait speed. Both the higher- and lower-intensity treadmill exercises improved cardiovascular fitness. Only the stretching and resistance exercises improved muscle strength. Therefore, exercise can improve gait speed, muscle strength, and fitness for patients with Parkinson disease. The combination of treadmill and resistance exercises may result in greater benefit and requires further investigation.</description><identifier>ISSN: 0003-9942</identifier><identifier>ISSN: 2168-6149</identifier><identifier>EISSN: 1538-3687</identifier><identifier>EISSN: 2168-6157</identifier><identifier>DOI: 10.1001/jamaneurol.2013.646</identifier><identifier>PMID: 23128427</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Aged ; Electrocardiography - methods ; Exercise - physiology ; Exercise Test - methods ; Female ; Gait - physiology ; Humans ; Male ; Middle Aged ; Muscle Stretching Exercises - methods ; Parkinson Disease - diagnosis ; Parkinson Disease - physiopathology ; Parkinson Disease - rehabilitation ; Prospective Studies ; Resistance Training - methods ; Single-Blind Method</subject><ispartof>Archives of neurology (Chicago), 2013-02, Vol.70 (2), p.1-8</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a424t-7ba2056e8752c145ce2d67ce7cc8a83f69f8608267bf423d76dea67bd3d8efcd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23128427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shulman, Lisa M</creatorcontrib><creatorcontrib>Katzel, Leslie I</creatorcontrib><creatorcontrib>Ivey, Frederick M</creatorcontrib><creatorcontrib>Sorkin, John D</creatorcontrib><creatorcontrib>Favors, Knachelle</creatorcontrib><creatorcontrib>Anderson, Karen E</creatorcontrib><creatorcontrib>Smith, Barbara A</creatorcontrib><creatorcontrib>Reich, Stephen G</creatorcontrib><creatorcontrib>Weiner, William J</creatorcontrib><creatorcontrib>Macko, Richard F</creatorcontrib><title>Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease</title><title>Archives of neurology (Chicago)</title><addtitle>JAMA Neurol</addtitle><description>OBJECTIVE To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. DESIGN A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise. SETTING The Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center. PATIENTS A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months. MAIN OUTCOME MEASURES The primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [[Vdot]O2], and muscle strength (1-repetition maximum strength). RESULTS All 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P = .001), stretching and resistance exercises (9% increase; P < .02), and higher-intensity treadmill exercise (6% increase; P = .07), with no between-group differences. Both treadmill exercises improved peak [Vdot]O2 (7%-8% increase; P < .05) more than did the stretching and resistance exercises. Only stretching and resistance improved muscle strength (16% increase; P < .001). CONCLUSIONS The effects of exercise were seen across all 3 exercise groups. The lower-intensity treadmill exercise resulted in the greatest improvement in gait speed. Both the higher- and lower-intensity treadmill exercises improved cardiovascular fitness. Only the stretching and resistance exercises improved muscle strength. Therefore, exercise can improve gait speed, muscle strength, and fitness for patients with Parkinson disease. The combination of treadmill and resistance exercises may result in greater benefit and requires further investigation.</description><subject>Adult</subject><subject>Aged</subject><subject>Electrocardiography - methods</subject><subject>Exercise - physiology</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>Gait - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Stretching Exercises - methods</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - rehabilitation</subject><subject>Prospective Studies</subject><subject>Resistance Training - methods</subject><subject>Single-Blind Method</subject><issn>0003-9942</issn><issn>2168-6149</issn><issn>1538-3687</issn><issn>2168-6157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVtPGzEQhS1UBOHyB1oJ7SMvG3xb2_uCVAVoKyGBqiCekOXYs43p7jrYG0T663EIt77YM5pzjkf-EPpG8JhgTE7uTWd6WMbQjikmbCy42EIjUjFVMqHkFzTCGLOyrjndRXsp3WcTVareQbuU5YpTOUJ3v03vQuf_gSsmre-9NW0xjT6foSlYMV0tIK3L6_kqvQzPnyBan6BoQiyuzeChH1Jx64d57uJf36fQF2dZYBIcoO3GtAkOX-99dHNxPp38LC-vfvyafL8sDad8KOXMUFwJULKilvDKAnVCWpDWKqNYI-pGCayokLOGU-akcGBy45hT0FjH9tHpJnexnHXgbF4pmlYvou9MXOlgvP5_0vu5_hMeNa8kr3GVA45fA2J4WEIadOeThbbNPxyWSRNaE4FljUWWso3UxpBShOb9GYL1Goz-AKPXYHQGk11Hnzd897yRyIKvG0E2fyQyVTMl2DNaVJbg</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Shulman, Lisa M</creator><creator>Katzel, Leslie I</creator><creator>Ivey, Frederick M</creator><creator>Sorkin, John D</creator><creator>Favors, Knachelle</creator><creator>Anderson, Karen E</creator><creator>Smith, Barbara A</creator><creator>Reich, Stephen G</creator><creator>Weiner, William J</creator><creator>Macko, Richard F</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease</title><author>Shulman, Lisa M ; Katzel, Leslie I ; Ivey, Frederick M ; Sorkin, John D ; Favors, Knachelle ; Anderson, Karen E ; Smith, Barbara A ; Reich, Stephen G ; Weiner, William J ; Macko, Richard F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a424t-7ba2056e8752c145ce2d67ce7cc8a83f69f8608267bf423d76dea67bd3d8efcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Electrocardiography - methods</topic><topic>Exercise - physiology</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>Gait - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Stretching Exercises - methods</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - rehabilitation</topic><topic>Prospective Studies</topic><topic>Resistance Training - methods</topic><topic>Single-Blind Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shulman, Lisa M</creatorcontrib><creatorcontrib>Katzel, Leslie I</creatorcontrib><creatorcontrib>Ivey, Frederick M</creatorcontrib><creatorcontrib>Sorkin, John D</creatorcontrib><creatorcontrib>Favors, Knachelle</creatorcontrib><creatorcontrib>Anderson, Karen E</creatorcontrib><creatorcontrib>Smith, Barbara A</creatorcontrib><creatorcontrib>Reich, Stephen G</creatorcontrib><creatorcontrib>Weiner, William J</creatorcontrib><creatorcontrib>Macko, Richard F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of neurology (Chicago)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shulman, Lisa M</au><au>Katzel, Leslie I</au><au>Ivey, Frederick M</au><au>Sorkin, John D</au><au>Favors, Knachelle</au><au>Anderson, Karen E</au><au>Smith, Barbara A</au><au>Reich, Stephen G</au><au>Weiner, William J</au><au>Macko, Richard F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease</atitle><jtitle>Archives of neurology (Chicago)</jtitle><addtitle>JAMA Neurol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>70</volume><issue>2</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0003-9942</issn><issn>2168-6149</issn><eissn>1538-3687</eissn><eissn>2168-6157</eissn><abstract>OBJECTIVE To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. DESIGN A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise. SETTING The Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center. PATIENTS A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months. MAIN OUTCOME MEASURES The primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [[Vdot]O2], and muscle strength (1-repetition maximum strength). RESULTS All 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P = .001), stretching and resistance exercises (9% increase; P < .02), and higher-intensity treadmill exercise (6% increase; P = .07), with no between-group differences. Both treadmill exercises improved peak [Vdot]O2 (7%-8% increase; P < .05) more than did the stretching and resistance exercises. Only stretching and resistance improved muscle strength (16% increase; P < .001). CONCLUSIONS The effects of exercise were seen across all 3 exercise groups. The lower-intensity treadmill exercise resulted in the greatest improvement in gait speed. Both the higher- and lower-intensity treadmill exercises improved cardiovascular fitness. Only the stretching and resistance exercises improved muscle strength. Therefore, exercise can improve gait speed, muscle strength, and fitness for patients with Parkinson disease. The combination of treadmill and resistance exercises may result in greater benefit and requires further investigation.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>23128427</pmid><doi>10.1001/jamaneurol.2013.646</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9942 |
| ispartof | Archives of neurology (Chicago), 2013-02, Vol.70 (2), p.1-8 |
| issn | 0003-9942 2168-6149 1538-3687 2168-6157 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4574905 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adult Aged Electrocardiography - methods Exercise - physiology Exercise Test - methods Female Gait - physiology Humans Male Middle Aged Muscle Stretching Exercises - methods Parkinson Disease - diagnosis Parkinson Disease - physiopathology Parkinson Disease - rehabilitation Prospective Studies Resistance Training - methods Single-Blind Method |
| title | Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T14%3A12%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Randomized%20Clinical%20Trial%20of%203%20Types%20of%20Physical%20Exercise%20for%20Patients%20With%20Parkinson%20Disease&rft.jtitle=Archives%20of%20neurology%20(Chicago)&rft.au=Shulman,%20Lisa%20M&rft.date=2013-02-01&rft.volume=70&rft.issue=2&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=0003-9942&rft.eissn=1538-3687&rft_id=info:doi/10.1001/jamaneurol.2013.646&rft_dat=%3Cproquest_pubme%3E1291607906%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1291607906&rft_id=info:pmid/23128427&rft_ama_id=1389386&rfr_iscdi=true |