Time‐trends in the prescribing of gastroprotective agents to primary care patients initiating low‐dose aspirin or non‐steroidal anti‐inflammatory drugs: a population‐based cohort study

Aims Low‐dose aspirin (LDA) and non‐steroidal‐anti‐inflammatory drugs (NSAIDs) both increase the risk of upper gastrointestinal events (UGIEs). In the Netherlands, recommendations regarding the prescription of gastroprotective agents (GPAs) in LDA users were first issued in 2009 in the HARM‐Wrestlin...

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Veröffentlicht in:	British journal of clinical pharmacology 2015-09, Vol.80 (3), p.589-598
Hauptverfasser:	Warlé‐van Herwaarden, Margaretha F., Koffeman, Aafke R., Valkhoff, Vera E., ’t Jong, Geert W., Kramers, Cornelis, Sturkenboom, Miriam C., De Smet, Peter A. G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Aspirin - administration & dosage Aspirin - adverse effects Cohort Studies Databases, Factual Dose-Response Relationship, Drug Drug Prescriptions - statistics & numerical data Female Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - prevention & control Gastrointestinal Hemorrhage - prevention & control gastrointestinal hemorrhages gastroprotective agents Humans low‐dose aspirin Male Middle Aged Netherlands NSAIDs Peptic Ulcer - prevention & control Pharmacoepidemiology Practice Guidelines as Topic Primary Health Care - methods Primary Health Care - statistics & numerical data Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - therapeutic use Risk Factors
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