Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion

There are an estimated 60,000 new cases of ductal carcinoma in situ (DCIS) each year. A lack of understanding in DCIS pathobiology has led to overtreatment of more than half of patients. We profiled the temporal molecular changes during DCIS transition to invasive ductal carcinoma (IDC) using in viv...

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Veröffentlicht in:	Breast cancer research : BCR 2015-09, Vol.17 (1), p.128-128, Article 128
Hauptverfasser:	Elsarraj, Hanan S, Hong, Yan, Valdez, Kelli E, Michaels, Whitney, Hook, Marcus, Smith, William P, Chien, Jeremy, Herschkowitz, Jason I, Troester, Melissa A, Beck, Moriah, Inciardi, Marc, Gatewood, Jason, May, Lisa, Cusick, Therese, McGinness, Marilee, Ricci, Lawrence, Fan, Fang, Tawfik, Ossama, Marks, Jeffrey R, Knapp, Jennifer R, Yeh, Hung-Wen, Thomas, Patricia, Carrasco, D R, Fields, Timothy A, Godwin, Andrew K, Behbod, Fariba
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals beta Catenin - genetics Biomarkers, Tumor - genetics Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Care and treatment Colon cancer Complications and side effects Disease Progression Epithelial-Mesenchymal Transition - genetics Estrogen Female Genes Genomics Humans Lymphomas Medical research Medicine, Experimental Mice Mice, Inbred NOD Mice, SCID Multiple myeloma Neoplasm Proteins - genetics Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Progesterone Receptor, ErbB-2 - genetics Receptors, Estrogen - genetics Receptors, Progesterone - genetics Risk factors RNA RNA sequencing Stem cells Transcription, Genetic - genetics Transcriptome - genetics Up-Regulation - genetics Wnt Proteins - genetics
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