Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer

Oxaliplatin-based chemotherapy exerts its effects through generating DNA damage. Hence, genetic variants in DNA repair pathways could modulate treatment response. We used a prospective cohort of 623 colorectal cancer patients with stage II–IV disease treated with adjuvant/palliative chemotherapy to...

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Veröffentlicht in:	The pharmacogenomics journal 2015-12, Vol.15 (6), p.505-512
Hauptverfasser:	Kap, E J, Seibold, P, Richter, S, Scherer, D, Habermann, N, Balavarca, Y, Jansen, L, Becker, N, Pfütze, K, Popanda, O, Hoffmeister, M, Ulrich, A, Benner, A, Ulrich, C M, Burwinkel, B, Brenner, H, Chang-Claude, J
Format:	Artikel
Sprache:	eng
Schlagworte:	45/77 692/53/2423 Aged Alleles Analysis Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cancer Care and treatment Case-Control Studies Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Deoxyribonucleic acid DNA DNA damage DNA repair DNA Repair - drug effects DNA Repair - genetics DNA-Binding Proteins - genetics Female Gene Expression Genetic diversity Genetic variance Genotype Health aspects Heterogeneity Human Genetics Humans Male Middle Aged Nucleotide excision repair Oncology Organoplatinum Compounds - therapeutic use original-article Oxaliplatin Pharmacotherapy Polymorphism, Single Nucleotide - genetics Prospective Studies Psychopharmacology Single nucleotide polymorphisms Single-nucleotide polymorphism Survival XPC protein
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