Pseudo-observations for competing risks with covariate dependent censoring
Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that...
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Veröffentlicht in: | Lifetime data analysis 2014-04, Vol.20 (2), p.303-315 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis. |
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ISSN: | 1380-7870 1572-9249 |
DOI: | 10.1007/s10985-013-9247-7 |