Acute Hypoxia Increases Ornithine Decarboxylase Activity and Polyamine Concentrations in Fetal Rat Brain

The cellular responses to hypoxia are poorly understood. To test the hypothesis that ornithine decarboxylase (ODC; L-ornithine carboxy-lyase; EC 4.1.1.17) activity and polyamine concentrations change in response to acute hypoxia, we performed the following studies. Pregnant Sprague-Dawley rats inspi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-01, Vol.90 (2), p.692-696
Hauptverfasser:	Longo, Lawrence D., Packianathan, Satyaseelan, McQueary, Jeffrey A., Stagg, Robert B., Byus, Craig V., Cain, Christopher D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animals Biogenic Polyamines - pharmacology Biological and medical sciences brain Brain - embryology Brain - enzymology Brain hypoxia Cerebellum concentration Dams DNA damage Embryology: invertebrates and vertebrates. Teratology enzymatic activity Female Fetal hypoxia Fetus Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Heat-Shock Proteins - analysis Hippocampus Hypoxia Hypoxia - enzymology Maternal-Fetal Exchange Messenger RNA Metabolism Ornithine - pharmacology ornithine decarboxylase Ornithine Decarboxylase - metabolism Oxygen Polyamines Pregnancy Propranolol - pharmacology Rats Rats, Sprague-Dawley - embryology RNA, Messenger - analysis Rodents Teratology. Teratogens Terbutaline - pharmacology Time Factors
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