REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury

Dendritic defects occur in neurodegenerative diseases accompanied by axonopathy, yet the mechanisms that regulate these pathologic changes are poorly understood. Using Thy1-YFPH mice subjected to optic nerve axotomy, we demonstrate early retraction of retinal ganglion cell (RGC) dendrites and select...

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Veröffentlicht in:	Cell death and differentiation 2015-04, Vol.22 (4), p.612-625
Hauptverfasser:	Morquette, B, Morquette, P, Agostinone, J, Feinstein, E, McKinney, R A, Kolta, A, Di Polo, A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1934 631/80/86 692/699/375/365 Alzheimer's disease Animals Apoptosis Axons - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Dendrites - drug effects Dendrites - physiology DNA damage Hypoxia Immunosuppressive Agents - pharmacology Kinases Life Sciences Mice Mice, Transgenic Morphology Nervous system Neurodegeneration Neurons Neurosciences Optic nerve Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology Original Paper Patch-Clamp Techniques Pathology Proteins Proteins - antagonists & inhibitors Proteins - genetics Proteins - metabolism Research centers Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism RNA Interference RNA, Small Interfering - metabolism Sirolimus - pharmacology Stem Cells Thy-1 Antigens - genetics TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Up-Regulation Variance analysis
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