Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma
AIM: To investigate the correlation between expression of vascular endothelial growth factor (VEGF) and cell differentiation, invasion, metastasis and Maspin expression in gastric carcinoma.METHODS: Formalin-fixed paraffin-embedded tissue specimens from 73 cases of gastric carcinoma were studied wit...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2004-09, Vol.10 (18), p.2624-2627 |
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| creator | Li, Jian-Jun Chen, Ying Zhang, Su-Min Wu, Dong-Ying Wang, Yan-Ping Xin, Yan |
| description | AIM: To investigate the correlation between expression of vascular endothelial growth factor (VEGF) and cell differentiation, invasion, metastasis and Maspin expression in gastric carcinoma.METHODS: Formalin-fixed paraffin-embedded tissue specimens from 73 cases of gastric carcinoma were studied with SP immunohistochemistry, using anti-VEGF monoclonal antibody, and thirty-nine of them were studied using antiMaspin monoclonal antibody. VEGF expression was compared with the clinical stage, lymph node metastasis, and Borrmann's and WHO's classification of gastric carcinoma.RESULTS: The positive rate of VEGF expression was significantly higher in adjacent non-carcinoma epithelia (ANCE) than in non-metaplastic, non-carcinoma gastric epithelia (NMNCE), which were at least 4 cm distant from the primary tumor (P = 0.000, x^2= 73.03). The positive rate of VEGF expression was significantly higher in advanced gastric carcinoma (AGC) than in early gastric carcinoma (EGC) (P = 0.032, x^2 = 4.62). The positive rate of VEGF expression in gastric carcinomas with lymph node metastases was significantly higher than that in those without metastasis (P = 0.006, x^2 = 7.47). Maspin was weakly expressed in 16 out of 39 cases of NMNCE, and the positive immunoreaction was limited to gland cells of the stomach body. There was no significant correlation between the expression of VEGF and histological or gross classifications, and correlation between the expressions of VEGF and Maspin in gastric carcinoma (P = 0.648, x^2 = 0.21).CONCLUSION: Expression of VEGF is significantly correlated to the malignant biological behaviors of gastric carcinoma,but there is no significant correlation between the expression of VEGF and Maspin. |
| doi_str_mv | 10.3748/wjg.v10.i18.2624 |
| format | Article |
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VEGF expression was compared with the clinical stage, lymph node metastasis, and Borrmann's and WHO's classification of gastric carcinoma.RESULTS: The positive rate of VEGF expression was significantly higher in adjacent non-carcinoma epithelia (ANCE) than in non-metaplastic, non-carcinoma gastric epithelia (NMNCE), which were at least 4 cm distant from the primary tumor (P = 0.000, x^2= 73.03). The positive rate of VEGF expression was significantly higher in advanced gastric carcinoma (AGC) than in early gastric carcinoma (EGC) (P = 0.032, x^2 = 4.62). The positive rate of VEGF expression in gastric carcinomas with lymph node metastases was significantly higher than that in those without metastasis (P = 0.006, x^2 = 7.47). Maspin was weakly expressed in 16 out of 39 cases of NMNCE, and the positive immunoreaction was limited to gland cells of the stomach body. There was no significant correlation between the expression of VEGF and histological or gross classifications, and correlation between the expressions of VEGF and Maspin in gastric carcinoma (P = 0.648, x^2 = 0.21).CONCLUSION: Expression of VEGF is significantly correlated to the malignant biological behaviors of gastric carcinoma,but there is no significant correlation between the expression of VEGF and Maspin.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v10.i18.2624</identifier><identifier>PMID: 15309707</identifier><language>eng</language><publisher>United States: No.4 Laboratory, Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China%Shenyang Gynecology and Obstetrics Hospital, Shenyang 110014, Liaoning Province, China</publisher><subject>Adenocarcinoma, Mucinous - metabolism ; Adenocarcinoma, Mucinous - secondary ; Adenocarcinoma, Papillary - metabolism ; Adenocarcinoma, Papillary - secondary ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Signet Ring Cell - metabolism ; Carcinoma, Signet Ring Cell - secondary ; Female ; Gastric Cancer ; Genes, Tumor Suppressor ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Proteins - metabolism ; Serpins - metabolism ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Vascular Endothelial Growth Factor A - metabolism ; VEGF ; 内皮细胞 ; 单克隆抗体 ; 基因表达 ; 生长因素 ; 病理学</subject><ispartof>World journal of gastroenterology : WJG, 2004-09, Vol.10 (18), p.2624-2627</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved. 2004</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-a9a7a5f591dd990b9f793190f935a61ebbd2f837ab8db2ee9ce9990b0b4bab9e3</citedby><cites>FETCH-LOGICAL-c514t-a9a7a5f591dd990b9f793190f935a61ebbd2f837ab8db2ee9ce9990b0b4bab9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572181/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572181/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15309707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jian-Jun</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Zhang, Su-Min</creatorcontrib><creatorcontrib>Wu, Dong-Ying</creatorcontrib><creatorcontrib>Wang, Yan-Ping</creatorcontrib><creatorcontrib>Xin, Yan</creatorcontrib><title>Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate the correlation between expression of vascular endothelial growth factor (VEGF) and cell differentiation, invasion, metastasis and Maspin expression in gastric carcinoma.METHODS: Formalin-fixed paraffin-embedded tissue specimens from 73 cases of gastric carcinoma were studied with SP immunohistochemistry, using anti-VEGF monoclonal antibody, and thirty-nine of them were studied using antiMaspin monoclonal antibody. VEGF expression was compared with the clinical stage, lymph node metastasis, and Borrmann's and WHO's classification of gastric carcinoma.RESULTS: The positive rate of VEGF expression was significantly higher in adjacent non-carcinoma epithelia (ANCE) than in non-metaplastic, non-carcinoma gastric epithelia (NMNCE), which were at least 4 cm distant from the primary tumor (P = 0.000, x^2= 73.03). The positive rate of VEGF expression was significantly higher in advanced gastric carcinoma (AGC) than in early gastric carcinoma (EGC) (P = 0.032, x^2 = 4.62). The positive rate of VEGF expression in gastric carcinomas with lymph node metastases was significantly higher than that in those without metastasis (P = 0.006, x^2 = 7.47). Maspin was weakly expressed in 16 out of 39 cases of NMNCE, and the positive immunoreaction was limited to gland cells of the stomach body. There was no significant correlation between the expression of VEGF and histological or gross classifications, and correlation between the expressions of VEGF and Maspin in gastric carcinoma (P = 0.648, x^2 = 0.21).CONCLUSION: Expression of VEGF is significantly correlated to the malignant biological behaviors of gastric carcinoma,but there is no significant correlation between the expression of VEGF and Maspin.</description><subject>Adenocarcinoma, Mucinous - metabolism</subject><subject>Adenocarcinoma, Mucinous - secondary</subject><subject>Adenocarcinoma, Papillary - metabolism</subject><subject>Adenocarcinoma, Papillary - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Signet Ring Cell - metabolism</subject><subject>Carcinoma, Signet Ring Cell - secondary</subject><subject>Female</subject><subject>Gastric Cancer</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Proteins - metabolism</subject><subject>Serpins - metabolism</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGF</subject><subject>内皮细胞</subject><subject>单克隆抗体</subject><subject>基因表达</subject><subject>生长因素</subject><subject>病理学</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc2P0zAQxS0EYruFOydkIcQtxR9JHV-QVitYkBbBAc7W2LETl9Tu2kkL_z2OWvFxskd-85vneQi9oGTDRd2-Pe36zbEUnrYbtmX1I7RijMqKtTV5jFaUEFFJzsQVus55RwjjvGFP0RVtOJGCiBWavsI0RO3jGHtvYMTZ98G7cg3G4ujwEbKZR0jYhi5Ogx19EfUpnqYBOzBTTBhChz9DPviA7c9Dsjn7GDIu5TDvIeAe8pS8wQaS8SHu4Rl64mDM9vnlXKPvH95_u_1Y3X-5-3R7c1-ZhtZTBRIENK6RtOukJFo6ITmVxEnewJZarTvmWi5At51m1kpj5aIjutagpeVr9O7MPcx6bztjw5RgVIfk95B-qQhe_f8S_KD6eFR1IxhtaQG8PgNOEByEXu3inEKxrMrmGSE1bZelrtGby5wUH2abJ7X32dhxhGDjnNV2K1oupShCchaaFHNO1v3xQolaEl24qiSqSqJqSbS0vPz3D38bLhEWwasLc4ihf_DFpQbzw_nRKkqLu0bW_Dfnzq1t</recordid><startdate>20040915</startdate><enddate>20040915</enddate><creator>Li, Jian-Jun</creator><creator>Chen, Ying</creator><creator>Zhang, Su-Min</creator><creator>Wu, Dong-Ying</creator><creator>Wang, Yan-Ping</creator><creator>Xin, Yan</creator><general>No.4 Laboratory, Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China%Shenyang Gynecology and Obstetrics Hospital, Shenyang 110014, Liaoning Province, China</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20040915</creationdate><title>Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma</title><author>Li, Jian-Jun ; 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VEGF expression was compared with the clinical stage, lymph node metastasis, and Borrmann's and WHO's classification of gastric carcinoma.RESULTS: The positive rate of VEGF expression was significantly higher in adjacent non-carcinoma epithelia (ANCE) than in non-metaplastic, non-carcinoma gastric epithelia (NMNCE), which were at least 4 cm distant from the primary tumor (P = 0.000, x^2= 73.03). The positive rate of VEGF expression was significantly higher in advanced gastric carcinoma (AGC) than in early gastric carcinoma (EGC) (P = 0.032, x^2 = 4.62). The positive rate of VEGF expression in gastric carcinomas with lymph node metastases was significantly higher than that in those without metastasis (P = 0.006, x^2 = 7.47). Maspin was weakly expressed in 16 out of 39 cases of NMNCE, and the positive immunoreaction was limited to gland cells of the stomach body. There was no significant correlation between the expression of VEGF and histological or gross classifications, and correlation between the expressions of VEGF and Maspin in gastric carcinoma (P = 0.648, x^2 = 0.21).CONCLUSION: Expression of VEGF is significantly correlated to the malignant biological behaviors of gastric carcinoma,but there is no significant correlation between the expression of VEGF and Maspin.</abstract><cop>United States</cop><pub>No.4 Laboratory, Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China%Shenyang Gynecology and Obstetrics Hospital, Shenyang 110014, Liaoning Province, China</pub><pmid>15309707</pmid><doi>10.3748/wjg.v10.i18.2624</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adenocarcinoma, Papillary - metabolism Adenocarcinoma, Papillary - secondary Adult Aged Aged, 80 and over Carcinoma, Signet Ring Cell - metabolism Carcinoma, Signet Ring Cell - secondary Female Gastric Cancer Genes, Tumor Suppressor Humans Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Proteins - metabolism Serpins - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Vascular Endothelial Growth Factor A - metabolism VEGF 内皮细胞 单克隆抗体 基因表达 生长因素 病理学 |
| title | Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma |
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