Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling

Arginine methylation is a common post-translational modification, but its role in regulating protein function is poorly understood. This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immune signaling, is regulated by reversible arginine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2015-09, Vol.290 (36), p.22236-22249
Hauptverfasser:	Tikhanovich, Irina, Kuravi, Sudhakiranmayi, Artigues, Antonio, Villar, Maria T., Dorko, Kenneth, Nawabi, Atta, Roberts, Benjamin, Weinman, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - metabolism arginine methylation Blotting, Western Cell Line Cell Line, Tumor Cells, Cultured endotoxin hepatocyte Humans Immunology innate immunity Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Jumonji domain-containing protein 6 Kinetics Ligands macrophage Male Methylation Mice, Inbred C57BL NF-kappa B - genetics NF-kappa B - metabolism post-translational modification protein arginine methyltransferase Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference Signal Transduction TNF receptor associated factor (TRAF) TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism toll-like receptor (TLR) Toll-Like Receptors - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!