Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin 1 and Their Influence on Spectral Tuning

The molecular mechanisms that regulate invertebrate visual pigment absorption are poorly understood. Studies of amphioxus Go-opsin have demonstrated that Glu-181 functions as the counterion in this pigment. This finding has led to the proposal that Glu-181 may function as the counterion in other inv...

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Veröffentlicht in:	The Journal of biological chemistry 2015-09, Vol.290 (36), p.21951-21961
Hauptverfasser:	Zheng, Lijun, Farrell, David M., Fulton, Ruth M., Bagg, Eve E., Salcedo, Ernesto, Manino, Meridee, Britt, Steven G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - chemistry Aspartic Acid - genetics Aspartic Acid - metabolism Blotting, Western Branchiostoma lanceolatum color perception Conserved Sequence - genetics Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Glutamic Acid - chemistry Glutamic Acid - genetics Glutamic Acid - metabolism Microspectrophotometry Mutation Neurobiology Opsins - classification Opsins - genetics Opsins - metabolism photoreceptor Phylogeny Protein Structure, Secondary retina Retinal Degeneration - genetics Retinal Degeneration - metabolism rhodopsin Rhodopsin - chemistry Rhodopsin - genetics Rhodopsin - metabolism site-directed mutagenesis
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