Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae

CutC choline trimethylamine-lyase is an anaerobic bacterial glycyl radical enzyme (GRE) that cleaves choline to produce trimethylamine (TMA) and acetaldehyde. In humans, TMA is produced exclusively by the intestinal microbiota, and its metabolite, trimethylamine oxide, has been associated with a hig...

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Veröffentlicht in:	The Journal of biological chemistry 2015-08, Vol.290 (35), p.21732-21740
Hauptverfasser:	Kalnins, Gints, Kuka, Janis, Grinberga, Solveiga, Makrecka-Kuka, Marina, Liepinsh, Edgars, Dambrova, Maija, Tars, Kaspars
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Catalytic Domain choline Choline - metabolism Chromatography, Gel Chymotrypsin - metabolism conformational change Electrophoresis, Polyacrylamide Gel enzyme catalysis enzyme structure Humans Klebsiella pneumoniae - enzymology Lyases - chemistry Lyases - metabolism Microbiota Models, Molecular Protein Multimerization Protein Structure and Folding Protein Structure, Tertiary radical Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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