Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation

Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide (NO)-responsive active form. We utilized fluorescence polarization measurements and hydrogen-deuter...

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Veröffentlicht in:	The Journal of biological chemistry 2015-08, Vol.290 (35), p.21615-21628
Hauptverfasser:	Sarkar, Anindya, Dai, Yue, Haque, Mohammad Mahfuzul, Seeger, Franziska, Ghosh, Arnab, Garcin, Elsa D, Montfort, William R, Hazen, Stanley L, Misra, Saurav, Stuehr, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cattle Cell Biology Deuterium Exchange Measurement Guanylate Cyclase - chemistry Guanylate Cyclase - metabolism Heme - metabolism HSP90 Heat-Shock Proteins - chemistry HSP90 Heat-Shock Proteins - metabolism Humans Kinetics Models, Molecular Molecular Sequence Data Protein Binding Protein Structure, Tertiary Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Soluble Guanylyl Cyclase
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