Donkey genome and insight into the imprinting of fast karyotype evolution
The donkey, like the horse, is a promising model for exploring karyotypic instability. We report the de novo whole-genome assemblies of the donkey and the Asiatic wild ass. Our results reflect the distinct characteristics of donkeys, including more effective energy metabolism and better immunity tha...
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| Veröffentlicht in: | Scientific reports 2015-09, Vol.5 (1), p.14106-14106, Article 14106 |
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| creator | Huang, Jinlong Zhao, Yiping Bai, Dongyi Shiraigol, Wunierfu Li, Bei Yang, Lihua Wu, Jing Bao, Wuyundalai Ren, Xiujuan Jin, Burenqiqige Zhao, Qinan Li, Anaer Bao, Sarula Bao, Wuyingga Xing, Zhencun An, Aoruga Gao, Yahan Wei, Ruiyuan Bao, Yirugeletu Bao, Taoketao Han, Haige Bai, Haitang Bao, Yanqing Zhang, Yuhong Daidiikhuu, Dorjsuren Zhao, Wenjing Liu, Shuyun Ding, Jinmei Ye, Weixing Ding, Fangmei Sun, Zikui Shi, Yixiang Zhang, Yan Meng, He Dugarjaviin, Manglai |
| description | The donkey, like the horse, is a promising model for exploring karyotypic instability. We report the de novo whole-genome assemblies of the donkey and the Asiatic wild ass. Our results reflect the distinct characteristics of donkeys, including more effective energy metabolism and better immunity than horses. The donkey shows a steady demographic trajectory. We detected abundant satellite sequences in some inactive centromere regions but not in neocentromere regions, while ribosomal RNAs frequently emerged in neocentromere regions but not in the obsolete centromere regions. Expanded miRNA families and five newly discovered miRNA target genes involved in meiosis may be associated with fast karyotype evolution. APC/C, controlling sister chromatid segregation, cytokinesis and the establishment of the G1 cell cycle phase were identified by analysis of miRNA targets and rapidly evolving genes. |
| doi_str_mv | 10.1038/srep14106 |
| format | Article |
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We report the de novo whole-genome assemblies of the donkey and the Asiatic wild ass. Our results reflect the distinct characteristics of donkeys, including more effective energy metabolism and better immunity than horses. The donkey shows a steady demographic trajectory. We detected abundant satellite sequences in some inactive centromere regions but not in neocentromere regions, while ribosomal RNAs frequently emerged in neocentromere regions but not in the obsolete centromere regions. Expanded miRNA families and five newly discovered miRNA target genes involved in meiosis may be associated with fast karyotype evolution. APC/C, controlling sister chromatid segregation, cytokinesis and the establishment of the G1 cell cycle phase were identified by analysis of miRNA targets and rapidly evolving genes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep14106</identifier><identifier>PMID: 26373886</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/211 ; 631/208/212 ; Animals ; Cell cycle ; Centromere - genetics ; Computational Biology - methods ; Equidae - genetics ; Evolution ; Evolution, Molecular ; Gene Rearrangement ; Genome ; Genomes ; Genomic Imprinting ; Genomics - methods ; Horses ; Humanities and Social Sciences ; Karyotype ; Karyotypes ; MicroRNAs - genetics ; Molecular Sequence Annotation ; multidisciplinary ; Repetitive Sequences, Nucleic Acid ; RNA Interference ; RNA, Messenger - genetics ; Science</subject><ispartof>Scientific reports, 2015-09, Vol.5 (1), p.14106-14106, Article 14106</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Sep 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ea30c0a041a595953535e8371e062d38d824dab9cc6f7684e439cb7770987c013</citedby><cites>FETCH-LOGICAL-c438t-ea30c0a041a595953535e8371e062d38d824dab9cc6f7684e439cb7770987c013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571621/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571621/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26373886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jinlong</creatorcontrib><creatorcontrib>Zhao, Yiping</creatorcontrib><creatorcontrib>Bai, Dongyi</creatorcontrib><creatorcontrib>Shiraigol, Wunierfu</creatorcontrib><creatorcontrib>Li, Bei</creatorcontrib><creatorcontrib>Yang, Lihua</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Bao, Wuyundalai</creatorcontrib><creatorcontrib>Ren, Xiujuan</creatorcontrib><creatorcontrib>Jin, Burenqiqige</creatorcontrib><creatorcontrib>Zhao, Qinan</creatorcontrib><creatorcontrib>Li, Anaer</creatorcontrib><creatorcontrib>Bao, Sarula</creatorcontrib><creatorcontrib>Bao, Wuyingga</creatorcontrib><creatorcontrib>Xing, Zhencun</creatorcontrib><creatorcontrib>An, Aoruga</creatorcontrib><creatorcontrib>Gao, Yahan</creatorcontrib><creatorcontrib>Wei, Ruiyuan</creatorcontrib><creatorcontrib>Bao, Yirugeletu</creatorcontrib><creatorcontrib>Bao, Taoketao</creatorcontrib><creatorcontrib>Han, Haige</creatorcontrib><creatorcontrib>Bai, Haitang</creatorcontrib><creatorcontrib>Bao, Yanqing</creatorcontrib><creatorcontrib>Zhang, Yuhong</creatorcontrib><creatorcontrib>Daidiikhuu, Dorjsuren</creatorcontrib><creatorcontrib>Zhao, Wenjing</creatorcontrib><creatorcontrib>Liu, Shuyun</creatorcontrib><creatorcontrib>Ding, Jinmei</creatorcontrib><creatorcontrib>Ye, Weixing</creatorcontrib><creatorcontrib>Ding, Fangmei</creatorcontrib><creatorcontrib>Sun, Zikui</creatorcontrib><creatorcontrib>Shi, Yixiang</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Meng, He</creatorcontrib><creatorcontrib>Dugarjaviin, Manglai</creatorcontrib><title>Donkey genome and insight into the imprinting of fast karyotype evolution</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The donkey, like the horse, is a promising model for exploring karyotypic instability. We report the de novo whole-genome assemblies of the donkey and the Asiatic wild ass. Our results reflect the distinct characteristics of donkeys, including more effective energy metabolism and better immunity than horses. The donkey shows a steady demographic trajectory. We detected abundant satellite sequences in some inactive centromere regions but not in neocentromere regions, while ribosomal RNAs frequently emerged in neocentromere regions but not in the obsolete centromere regions. Expanded miRNA families and five newly discovered miRNA target genes involved in meiosis may be associated with fast karyotype evolution. APC/C, controlling sister chromatid segregation, cytokinesis and the establishment of the G1 cell cycle phase were identified by analysis of miRNA targets and rapidly evolving genes.</description><subject>631/208/211</subject><subject>631/208/212</subject><subject>Animals</subject><subject>Cell cycle</subject><subject>Centromere - genetics</subject><subject>Computational Biology - methods</subject><subject>Equidae - genetics</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Gene Rearrangement</subject><subject>Genome</subject><subject>Genomes</subject><subject>Genomic Imprinting</subject><subject>Genomics - methods</subject><subject>Horses</subject><subject>Humanities and Social Sciences</subject><subject>Karyotype</subject><subject>Karyotypes</subject><subject>MicroRNAs - genetics</subject><subject>Molecular Sequence Annotation</subject><subject>multidisciplinary</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>RNA Interference</subject><subject>RNA, Messenger - 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| subjects | 631/208/211 631/208/212 Animals Cell cycle Centromere - genetics Computational Biology - methods Equidae - genetics Evolution Evolution, Molecular Gene Rearrangement Genome Genomes Genomic Imprinting Genomics - methods Horses Humanities and Social Sciences Karyotype Karyotypes MicroRNAs - genetics Molecular Sequence Annotation multidisciplinary Repetitive Sequences, Nucleic Acid RNA Interference RNA, Messenger - genetics Science |
| title | Donkey genome and insight into the imprinting of fast karyotype evolution |
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