Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets

CREB‑H, an endoplasmic reticulum-anchored transcription factor, plays a key role in regulating secretion and in metabolic and inflammatory pathways, but how its activity is modulated remains unclear. We examined processing of the nuclear active form and identified a motif around S87-S90 with homolog...

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Veröffentlicht in:	Molecular biology of the cell 2015-08, Vol.26 (16), p.2939-2954
Hauptverfasser:	Barbosa, Sónia, Carreira, Suzanne, Bailey, Daniel, Abaitua, Fernando, O'Hare, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Conserved Sequence Cyclic AMP Response Element-Binding Protein - metabolism Endoplasmic Reticulum - metabolism Hep G2 Cells Humans Mice Phosphorylation Regulatory Elements, Transcriptional Signal Transduction - genetics SKP Cullin F-Box Protein Ligases - metabolism Ubiquitin - metabolism
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