Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity

Hypoxia could lead to microglia activation and inflammatory mediators' overproduction. These inflammatory molecules could amplify the neuroinflammatory process and exacerbate neuronal injury. The aim of this study is to find out whether harpagoside could reduce hypoxia-induced microglia activat...

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Veröffentlicht in:	BMC complementary and alternative medicine 2015-09, Vol.15 (1), p.324-324, Article 324
Hauptverfasser:	Sheu, Shiow-Yunn, Hong, Yi-Wen, Sun, Jui-Sheng, Liu, Man-Hai, Chen, Ching-Yun, Ke, Cherng-Jyh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals complement cytosol cytotoxicity Gene expression Gene Expression - drug effects Genes Glycosides - pharmacology hypoxia Hypoxia - metabolism Inflammation Inflammation - metabolism interleukin-6 Mice Mice, Inbred ICR Microglia - drug effects neuroglia neurons neurotoxicity Physiological aspects Plant Extracts - pharmacology Protective Agents - pharmacology protein phosphorylation protein transport Pyrans - pharmacology Scrophularia - chemistry toxicity testing
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