A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alte...

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Veröffentlicht in:	Nat. Commun 2015-09, Vol.6 (1), p.8143-8143, Article 8143
Hauptverfasser:	Krarup, Anders, Truan, Daphné, Furmanova-Hollenstein, Polina, Bogaert, Lies, Bouchier, Pascale, Bisschop, Ilona J. M., Widjojoatmodjo, Myra N., Zahn, Roland, Schuitemaker, Hanneke, McLellan, Jason S., Langedijk, Johannes P. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	42/70 631/326/596 631/45/535 631/61/24/590/2294 64/60 82/58 82/80 82/83 96/109 96/34 Animals Antibodies Antibodies, Neutralizing - immunology Antigens Antigens, Viral - genetics Antigens, Viral - immunology Blotting, Western Crystallization Crystallography, X-Ray Disease Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Humanities and Social Sciences Mice Microscopy, Electron multidisciplinary Mutation Peptides Protein Conformation Proteins Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Viruses - genetics Respiratory Syncytial Viruses - immunology Science Science (multidisciplinary) Sigmodontinae Vaccines Viral Fusion Proteins - genetics Viral Fusion Proteins - immunology
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