Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients
The objective of this study was to identify predictors of insulin independence and to establish the best clinical tools to follow patients after pancreatic islet transplantation (PIT). Sequential metabolic responses to intravenous (I.V.) glucose (I.V. glucose tolerance test [IVGTT]), arginine and gl...
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| Veröffentlicht in: | American journal of transplantation 2012-05, Vol.12 (5), p.1275-1289 |
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| creator | Hirsch, D. Odorico, J. Danobeitia, J. S. Alejandro, R. Rickels, M. R. Hanson, M. Radke, N. Baidal, D. Hullett, D. Naji, A. Ricordi, C. Kaufman, D. Fernandez, L. |
| description | The objective of this study was to identify predictors of insulin independence and to establish the best clinical tools to follow patients after pancreatic islet transplantation (PIT). Sequential metabolic responses to intravenous (I.V.) glucose (I.V. glucose tolerance test [IVGTT]), arginine and glucose‐potentiated arginine (glucose‐potentiated arginine‐induced insulin secretion [GPAIS]) were obtained from 30 patients. We determined the correlation between transplanted islet mass and islet engraftment and tested the ability of each assay to predict return to exogenous insulin therapy. We found transplanted islet mass within an average of 16 709 islet equivalents per kg body weight (IEQ/kg BW; range between 6602 and 29 614 IEQ/kg BW) to be a poor predictor of insulin independence at 1 year, having a poor correlation between transplanted islet mass and islet engraftment. Acute insulin response to IVGTT (AIRGLU) and GPAIS (AIRmax) were the most accurate methods to determine suboptimal islet mass engraftment. AIRGLU performed 3 months after transplant also proved to be a robust early metabolic marker to predict return to insulin therapy and its value was positively correlated with duration of insulin independence. In conclusion, AIRGLU is an early metabolic assay capable of anticipating loss of insulin independence at 1 year in T1D patients undergoing PIT and constitutes a valuable, simple and reliable method to follow patients after transplant.
Acute insulin response to an intravenous glucose tolerance test is the most reliable predictor of insulin independence at one year after pancreatic islet transplantation in type 1 diabetic recipients. |
| doi_str_mv | 10.1111/j.1600-6143.2011.03947.x |
| format | Article |
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Acute insulin response to an intravenous glucose tolerance test is the most reliable predictor of insulin independence at one year after pancreatic islet transplantation in type 1 diabetic recipients.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2011.03947.x</identifier><identifier>PMID: 22300172</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - metabolism ; C-Peptide - blood ; C-Peptide - metabolism ; Case-Control Studies ; Clinical islet transplantation ; Diabetes Mellitus, Type 1 - surgery ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Glucose Tolerance Test ; Graft Rejection - blood ; Graft Rejection - diagnosis ; Graft Rejection - etiology ; Humans ; Insulin - blood ; Insulin - metabolism ; insulin independence ; Insulin Secretion ; Islets of Langerhans - pathology ; Islets of Langerhans Transplantation - adverse effects ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Transplantation, Homologous ; Young Adult</subject><ispartof>American journal of transplantation, 2012-05, Vol.12 (5), p.1275-1289</ispartof><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5377-d993a13e243668ea50d4f90af0af47737225e192b394a7500c0db817b6b8fb0b3</citedby><cites>FETCH-LOGICAL-c5377-d993a13e243668ea50d4f90af0af47737225e192b394a7500c0db817b6b8fb0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2011.03947.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2011.03947.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25963170$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22300172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirsch, D.</creatorcontrib><creatorcontrib>Odorico, J.</creatorcontrib><creatorcontrib>Danobeitia, J. S.</creatorcontrib><creatorcontrib>Alejandro, R.</creatorcontrib><creatorcontrib>Rickels, M. R.</creatorcontrib><creatorcontrib>Hanson, M.</creatorcontrib><creatorcontrib>Radke, N.</creatorcontrib><creatorcontrib>Baidal, D.</creatorcontrib><creatorcontrib>Hullett, D.</creatorcontrib><creatorcontrib>Naji, A.</creatorcontrib><creatorcontrib>Ricordi, C.</creatorcontrib><creatorcontrib>Kaufman, D.</creatorcontrib><creatorcontrib>Fernandez, L.</creatorcontrib><title>Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>The objective of this study was to identify predictors of insulin independence and to establish the best clinical tools to follow patients after pancreatic islet transplantation (PIT). Sequential metabolic responses to intravenous (I.V.) glucose (I.V. glucose tolerance test [IVGTT]), arginine and glucose‐potentiated arginine (glucose‐potentiated arginine‐induced insulin secretion [GPAIS]) were obtained from 30 patients. We determined the correlation between transplanted islet mass and islet engraftment and tested the ability of each assay to predict return to exogenous insulin therapy. We found transplanted islet mass within an average of 16 709 islet equivalents per kg body weight (IEQ/kg BW; range between 6602 and 29 614 IEQ/kg BW) to be a poor predictor of insulin independence at 1 year, having a poor correlation between transplanted islet mass and islet engraftment. Acute insulin response to IVGTT (AIRGLU) and GPAIS (AIRmax) were the most accurate methods to determine suboptimal islet mass engraftment. AIRGLU performed 3 months after transplant also proved to be a robust early metabolic marker to predict return to insulin therapy and its value was positively correlated with duration of insulin independence. In conclusion, AIRGLU is an early metabolic assay capable of anticipating loss of insulin independence at 1 year in T1D patients undergoing PIT and constitutes a valuable, simple and reliable method to follow patients after transplant.
Acute insulin response to an intravenous glucose tolerance test is the most reliable predictor of insulin independence at one year after pancreatic islet transplantation in type 1 diabetic recipients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>C-Peptide - blood</subject><subject>C-Peptide - metabolism</subject><subject>Case-Control Studies</subject><subject>Clinical islet transplantation</subject><subject>Diabetes Mellitus, Type 1 - surgery</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose Tolerance Test</subject><subject>Graft Rejection - blood</subject><subject>Graft Rejection - diagnosis</subject><subject>Graft Rejection - etiology</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>insulin independence</subject><subject>Insulin Secretion</subject><subject>Islets of Langerhans - pathology</subject><subject>Islets of Langerhans Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUd9v0zAQjhCIjcG_gPyCxEsz_0ji-AGkamxQ1AkJlWfr7Fw2FzcJdsrW_x5n7Qo8gWX57nTffXfnL8sIozlL53yds4rSWcUKkXPKWE6FKmR-_yQ7PSaeHn1RnmQvYlxTyiSv-fPshHPxEJxm4RKC35FrHMH03llyDeE7hkhWtzCSeTc66wYYkSz7GEnfkkUXt951yTY4YHo6iyTFq92AhJEPDgymIrKIHhOB9_1NgHYkXzEROezG-DJ71oKP-Opgz7JvV5eri0-z5ZePi4v5cmZLIeWsUUoAE8gLUVU1QkmbolUU2nQLKYXkvESmuEmrgywptbQxNZOmMnVrqBFn2fs977A1G2xs6h3A6yG4DYSd7sHpvzOdu9U3_U9dlJViRZkI3h4IQv9ji3HUGxcteg8d9tuomaxLLmpF5b-hlCmqmKom1noPtSF9acD2OBGjelJXr_UknJ5E1JO6-kFdfZ9KX_-50bHwUc4EeHMAQLTg2wCddfE3rlSVYJIm3Ls97s553P33AHr-eTV54heM6sBJ</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Hirsch, D.</creator><creator>Odorico, J.</creator><creator>Danobeitia, J. S.</creator><creator>Alejandro, R.</creator><creator>Rickels, M. R.</creator><creator>Hanson, M.</creator><creator>Radke, N.</creator><creator>Baidal, D.</creator><creator>Hullett, D.</creator><creator>Naji, A.</creator><creator>Ricordi, C.</creator><creator>Kaufman, D.</creator><creator>Fernandez, L.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201205</creationdate><title>Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients</title><author>Hirsch, D. ; Odorico, J. ; Danobeitia, J. S. ; Alejandro, R. ; Rickels, M. 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Target tissue resistance</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose Tolerance Test</topic><topic>Graft Rejection - blood</topic><topic>Graft Rejection - diagnosis</topic><topic>Graft Rejection - etiology</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>insulin independence</topic><topic>Insulin Secretion</topic><topic>Islets of Langerhans - pathology</topic><topic>Islets of Langerhans Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirsch, D.</creatorcontrib><creatorcontrib>Odorico, J.</creatorcontrib><creatorcontrib>Danobeitia, J. 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S.</au><au>Alejandro, R.</au><au>Rickels, M. R.</au><au>Hanson, M.</au><au>Radke, N.</au><au>Baidal, D.</au><au>Hullett, D.</au><au>Naji, A.</au><au>Ricordi, C.</au><au>Kaufman, D.</au><au>Fernandez, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2012-05</date><risdate>2012</risdate><volume>12</volume><issue>5</issue><spage>1275</spage><epage>1289</epage><pages>1275-1289</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>The objective of this study was to identify predictors of insulin independence and to establish the best clinical tools to follow patients after pancreatic islet transplantation (PIT). Sequential metabolic responses to intravenous (I.V.) glucose (I.V. glucose tolerance test [IVGTT]), arginine and glucose‐potentiated arginine (glucose‐potentiated arginine‐induced insulin secretion [GPAIS]) were obtained from 30 patients. We determined the correlation between transplanted islet mass and islet engraftment and tested the ability of each assay to predict return to exogenous insulin therapy. We found transplanted islet mass within an average of 16 709 islet equivalents per kg body weight (IEQ/kg BW; range between 6602 and 29 614 IEQ/kg BW) to be a poor predictor of insulin independence at 1 year, having a poor correlation between transplanted islet mass and islet engraftment. Acute insulin response to IVGTT (AIRGLU) and GPAIS (AIRmax) were the most accurate methods to determine suboptimal islet mass engraftment. AIRGLU performed 3 months after transplant also proved to be a robust early metabolic marker to predict return to insulin therapy and its value was positively correlated with duration of insulin independence. In conclusion, AIRGLU is an early metabolic assay capable of anticipating loss of insulin independence at 1 year in T1D patients undergoing PIT and constitutes a valuable, simple and reliable method to follow patients after transplant.
Acute insulin response to an intravenous glucose tolerance test is the most reliable predictor of insulin independence at one year after pancreatic islet transplantation in type 1 diabetic recipients.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>22300172</pmid><doi>10.1111/j.1600-6143.2011.03947.x</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers - blood Blood Glucose - metabolism C-Peptide - blood C-Peptide - metabolism Case-Control Studies Clinical islet transplantation Diabetes Mellitus, Type 1 - surgery Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies Glucose Tolerance Test Graft Rejection - blood Graft Rejection - diagnosis Graft Rejection - etiology Humans Insulin - blood Insulin - metabolism insulin independence Insulin Secretion Islets of Langerhans - pathology Islets of Langerhans Transplantation - adverse effects Male Medical sciences Middle Aged Postoperative Complications Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Homologous Young Adult |
| title | Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients |
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