Control of cell cycle transcription during G1 and S phases

Key Points The G1–S transcriptional programme is robustly activated by positive feedback mechanisms, creating an 'all-or-none' switch that leads to cell cycle commitment. Inactivation of G1–S transcription in both yeast and humans involves negative feedback loops. The wave of G1–S transcri...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2013-08, Vol.14 (8), p.518-528
Hauptverfasser:	Bertoli, Cosetta, Skotheim, Jan M., de Bruin, Robertus A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	81 Animals Biochemistry Biology Cancer Research Cell Biology Cell cycle Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Proteins - genetics Cell division Control Cyclin-dependent kinases Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cyclin-Dependent Kinases - physiology Deoxyribonucleic acid Developmental Biology DNA Feedback G1 Phase - genetics G1 Phase - physiology Gene expression Genetic transcription Genomes Humans Inactivation Kinases Life Sciences Mammals Mammals - genetics Mammals - physiology Models, Biological Phase transitions Physiological aspects Proteins review-article S Phase - genetics S Phase - physiology Stem Cells Transcription factors Transcription, Genetic - physiology Yeast Yeasts Yeasts - genetics Yeasts - physiology
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