Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study

Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the...

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Veröffentlicht in:	Clinical microbiology and infection 2013-05, Vol.19 (5), p.E222-E229
Hauptverfasser:	McMillan, D.J., Drèze, P. -A., Vu, T., Bessen, D.E., Guglielmini, J., Steer, A.C., Carapetis, J.R., Van Melderen, L., Sriprakash, K.S., Smeesters, P.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacteriology Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - immunology DNA, Bacterial - chemistry DNA, Bacterial - genetics Epidemiology Epitope Mapping Epitopes - genetics Epitopes - immunology Genetic Variation Global Health Humans Life Sciences M protein Microbiology and Parasitology Models, Molecular Molecular Sequence Data Protein Conformation Proteins Sequence Analysis, DNA Streptococcal Infections - microbiology Streptococcus Streptococcus pyogenes Streptococcus pyogenes - chemistry Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Streptococcus pyogenes - isolation & purification typing vaccine Vaccines virulence
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