Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study
Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the...
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| creator | McMillan, D.J. Drèze, P. -A. Vu, T. Bessen, D.E. Guglielmini, J. Steer, A.C. Carapetis, J.R. Van Melderen, L. Sriprakash, K.S. Smeesters, P.R. |
| description | Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies. |
| doi_str_mv | 10.1111/1469-0691.12134 |
| format | Article |
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Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/1469-0691.12134</identifier><identifier>PMID: 23464795</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antigens, Bacterial - chemistry ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; Bacterial Outer Membrane Proteins - chemistry ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Outer Membrane Proteins - immunology ; Bacteriology ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Carrier Proteins - immunology ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Epidemiology ; Epitope Mapping ; Epitopes - genetics ; Epitopes - immunology ; Genetic Variation ; Global Health ; Humans ; Life Sciences ; M protein ; Microbiology and Parasitology ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Proteins ; Sequence Analysis, DNA ; Streptococcal Infections - microbiology ; Streptococcus ; Streptococcus pyogenes ; Streptococcus pyogenes - chemistry ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - immunology ; Streptococcus pyogenes - isolation & purification ; typing ; vaccine ; Vaccines ; virulence</subject><ispartof>Clinical microbiology and infection, 2013-05, Vol.19 (5), p.E222-E229</ispartof><rights>2013 European Society of Clinical Infectious Diseases</rights><rights>2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.</rights><rights>Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6504-345a1d90e8b8f067a7f3c5d73760ac98da712ebc7a5d76ab6ffc5131d5f7ca213</citedby><cites>FETCH-LOGICAL-c6504-345a1d90e8b8f067a7f3c5d73760ac98da712ebc7a5d76ab6ffc5131d5f7ca213</cites><orcidid>0000-0002-8566-1726</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1469-0691.12134$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1469-0691.12134$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23464795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03259578$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>McMillan, D.J.</creatorcontrib><creatorcontrib>Drèze, P. -A.</creatorcontrib><creatorcontrib>Vu, T.</creatorcontrib><creatorcontrib>Bessen, D.E.</creatorcontrib><creatorcontrib>Guglielmini, J.</creatorcontrib><creatorcontrib>Steer, A.C.</creatorcontrib><creatorcontrib>Carapetis, J.R.</creatorcontrib><creatorcontrib>Van Melderen, L.</creatorcontrib><creatorcontrib>Sriprakash, K.S.</creatorcontrib><creatorcontrib>Smeesters, P.R.</creatorcontrib><title>Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies.</description><subject>Antigens, Bacterial - chemistry</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Outer Membrane Proteins - chemistry</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacteriology</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - immunology</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Epidemiology</subject><subject>Epitope Mapping</subject><subject>Epitopes - genetics</subject><subject>Epitopes - immunology</subject><subject>Genetic Variation</subject><subject>Global Health</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>M protein</subject><subject>Microbiology and Parasitology</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Protein Conformation</subject><subject>Proteins</subject><subject>Sequence Analysis, DNA</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - chemistry</subject><subject>Streptococcus pyogenes - genetics</subject><subject>Streptococcus pyogenes - immunology</subject><subject>Streptococcus pyogenes - isolation & purification</subject><subject>typing</subject><subject>vaccine</subject><subject>Vaccines</subject><subject>virulence</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEoqVw5oYscYFDWjv-Si5IqxVQpK04QCXExXLsSddVEgc72dX-exzSrqASAl9sjZ95Zzyvs-wlweckrQvCRJVjUZFzUhDKHmWnx8jjdCZVmUtGv51kz2K8xRgXlLKn2UlBmWCy4qfZ9-vB6hEs6ryFFvkG3QQ_DWiFvowBhtEbb8wU0RUagh_B9RHVOibe90gj47shwBb66HaA9j60du8soDhO9vA8e9LoNsKLu_0su_7w_uv6Mt98_vhpvdrkRnDMcsq4JrbCUNZlg4XUsqGGW0mlwNpUpdWSFFAbqVNQ6Fo0jeGEEssbaXR69Vn2btEdproDa6Afg27VEFynw0F57dSfN73bqhu_U4yLsuIyCbxdBLYP0i5XGzXHMC14AsvdXOzNXbHgf0wQR9W5aKBtdQ9-iopQIVnJqKD_gRZCUkJKkdDXD9BbP4U-TU0RXlSCCYxnwYuFMsHHGKA5Nkuwmr-Dms1Xs_nq13dIGa9-H82Rv_c_AXwB9q6Fw7_01HpzdS9cLXmQjN05CCoaB70B6wKYUVnv_trUT3Ik0SU</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>McMillan, D.J.</creator><creator>Drèze, P. -A.</creator><creator>Vu, T.</creator><creator>Bessen, D.E.</creator><creator>Guglielmini, J.</creator><creator>Steer, A.C.</creator><creator>Carapetis, J.R.</creator><creator>Van Melderen, L.</creator><creator>Sriprakash, K.S.</creator><creator>Smeesters, P.R.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>Elsevier for the European Society of Clinical Microbiology and Infectious Diseases</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8566-1726</orcidid></search><sort><creationdate>201305</creationdate><title>Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study</title><author>McMillan, D.J. ; Drèze, P. -A. ; Vu, T. ; Bessen, D.E. ; Guglielmini, J. ; Steer, A.C. ; Carapetis, J.R. ; Van Melderen, L. ; Sriprakash, K.S. ; Smeesters, P.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6504-345a1d90e8b8f067a7f3c5d73760ac98da712ebc7a5d76ab6ffc5131d5f7ca213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antigens, Bacterial - chemistry</topic><topic>Antigens, Bacterial - genetics</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial Outer Membrane Proteins - chemistry</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacteriology</topic><topic>Carrier Proteins - chemistry</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - immunology</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>Epidemiology</topic><topic>Epitope Mapping</topic><topic>Epitopes - genetics</topic><topic>Epitopes - immunology</topic><topic>Genetic Variation</topic><topic>Global Health</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>M protein</topic><topic>Microbiology and Parasitology</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>Protein Conformation</topic><topic>Proteins</topic><topic>Sequence Analysis, DNA</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - chemistry</topic><topic>Streptococcus pyogenes - genetics</topic><topic>Streptococcus pyogenes - immunology</topic><topic>Streptococcus pyogenes - isolation & purification</topic><topic>typing</topic><topic>vaccine</topic><topic>Vaccines</topic><topic>virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McMillan, D.J.</creatorcontrib><creatorcontrib>Drèze, P. -A.</creatorcontrib><creatorcontrib>Vu, T.</creatorcontrib><creatorcontrib>Bessen, D.E.</creatorcontrib><creatorcontrib>Guglielmini, J.</creatorcontrib><creatorcontrib>Steer, A.C.</creatorcontrib><creatorcontrib>Carapetis, J.R.</creatorcontrib><creatorcontrib>Van Melderen, L.</creatorcontrib><creatorcontrib>Sriprakash, K.S.</creatorcontrib><creatorcontrib>Smeesters, P.R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McMillan, D.J.</au><au>Drèze, P. -A.</au><au>Vu, T.</au><au>Bessen, D.E.</au><au>Guglielmini, J.</au><au>Steer, A.C.</au><au>Carapetis, J.R.</au><au>Van Melderen, L.</au><au>Sriprakash, K.S.</au><au>Smeesters, P.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2013-05</date><risdate>2013</risdate><volume>19</volume><issue>5</issue><spage>E222</spage><epage>E229</epage><pages>E222-E229</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23464795</pmid><doi>10.1111/1469-0691.12134</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8566-1726</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacteriology Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - immunology DNA, Bacterial - chemistry DNA, Bacterial - genetics Epidemiology Epitope Mapping Epitopes - genetics Epitopes - immunology Genetic Variation Global Health Humans Life Sciences M protein Microbiology and Parasitology Models, Molecular Molecular Sequence Data Protein Conformation Proteins Sequence Analysis, DNA Streptococcal Infections - microbiology Streptococcus Streptococcus pyogenes Streptococcus pyogenes - chemistry Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Streptococcus pyogenes - isolation & purification typing vaccine Vaccines virulence |
| title | Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study |
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