Progressive retinal structure abnormalities in multiple system atrophy
ABSTRACT Background Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression. Methods Th...
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| Veröffentlicht in: | Movement disorders 2015-12, Vol.30 (14), p.1944-1953 |
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| creator | Mendoza-Santiesteban, Carlos E. Palma, Jose-Alberto Martinez, Jose Norcliffe-Kaufmann, Lucy Hedges III, Thomas R. Kaufmann, Horacio |
| description | ABSTRACT
Background
Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.
Methods
This was a cross‐sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high‐definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow‐up visits for up to 26 months.
Results
MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (P = 0.008 and P = 0.001) and ganglion cell complex (P = 0.013 and P = 0.001) thicknesses were reduced in MSA and PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 and 1.8 μm, respectively.
Conclusions
Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high‐definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. © 2015 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.26360 |
| format | Article |
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Background
Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.
Methods
This was a cross‐sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high‐definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow‐up visits for up to 26 months.
Results
MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (P = 0.008 and P = 0.001) and ganglion cell complex (P = 0.013 and P = 0.001) thicknesses were reduced in MSA and PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 and 1.8 μm, respectively.
Conclusions
Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high‐definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. © 2015 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.26360</identifier><identifier>PMID: 26359930</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Color Perception - physiology ; Cross-Sectional Studies ; Disease Progression ; Female ; ganglion cell complex ; Humans ; Male ; Middle Aged ; Movement disorders ; multiple system atrophy ; Multiple System Atrophy - pathology ; Multiple System Atrophy - physiopathology ; optical coherence tomography ; Parkinson disease ; Retina - pathology ; Retina - physiopathology ; retinal nerve fiber layer ; Tomography, Optical Coherence ; unified multiple system atrophy rating scale ; Visual Acuity - physiology</subject><ispartof>Movement disorders, 2015-12, Vol.30 (14), p.1944-1953</ispartof><rights>2015 International Parkinson and Movement Disorder Society</rights><rights>2015 International Parkinson and Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5840-a7d1e317dd1d6260e6792ce60ddfcc18c71a5ec085cffd24a9dae3bf57028d463</citedby><cites>FETCH-LOGICAL-c5840-a7d1e317dd1d6260e6792ce60ddfcc18c71a5ec085cffd24a9dae3bf57028d463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.26360$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.26360$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26359930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendoza-Santiesteban, Carlos E.</creatorcontrib><creatorcontrib>Palma, Jose-Alberto</creatorcontrib><creatorcontrib>Martinez, Jose</creatorcontrib><creatorcontrib>Norcliffe-Kaufmann, Lucy</creatorcontrib><creatorcontrib>Hedges III, Thomas R.</creatorcontrib><creatorcontrib>Kaufmann, Horacio</creatorcontrib><title>Progressive retinal structure abnormalities in multiple system atrophy</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>ABSTRACT
Background
Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.
Methods
This was a cross‐sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high‐definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow‐up visits for up to 26 months.
Results
MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (P = 0.008 and P = 0.001) and ganglion cell complex (P = 0.013 and P = 0.001) thicknesses were reduced in MSA and PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 and 1.8 μm, respectively.
Conclusions
Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high‐definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. © 2015 International Parkinson and Movement Disorder Society</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Color Perception - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>ganglion cell complex</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>multiple system atrophy</subject><subject>Multiple System Atrophy - pathology</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>optical coherence tomography</subject><subject>Parkinson disease</subject><subject>Retina - pathology</subject><subject>Retina - physiopathology</subject><subject>retinal nerve fiber layer</subject><subject>Tomography, Optical Coherence</subject><subject>unified multiple system atrophy rating scale</subject><subject>Visual Acuity - physiology</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9PFDEYBvDGaGRFD34BM4kXPQy00-mfuZgYFISAkqjgrem270CxM13bDrrfnq4LGzExMT300F-ftO-D0HOCdwjGze5g007DKccP0IwwSmrZMPEQzbCUrKZEsi30JKUrjAlhhD9GWwWzrqN4hvZPY7iIkJK7hipCdqP2VcpxMnmKUOn5GOKgvcsOUuXGaph8dgsPVVqmDEOlcwyLy-VT9KjXPsGz230bfd1__2XvQ3386eBw7-1xbZhsca2FJUCJsJZY3nAMXHSNAY6t7Y0h0giiGRgsmel727S6sxrovGcCN9K2nG6jN-vcxTQfwBoYc9ReLaIbdFyqoJ26fzK6S3URrlXLuBRMloBXtwEx_JggZTW4ZMB7PUKYkiJCYkZE2_wP5Vh2uMNtoS__oldhimWUK8XKWg27qNdrZWJIKUK_eTfBalWkKkWq30UW--LPj27kXXMF7K7BT-dh-e8kdfLu811kvb7hSnO_Njd0_K64oIKp848H6uz0hLZn347UOb0BoZW4rg</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Mendoza-Santiesteban, Carlos E.</creator><creator>Palma, Jose-Alberto</creator><creator>Martinez, Jose</creator><creator>Norcliffe-Kaufmann, Lucy</creator><creator>Hedges III, Thomas R.</creator><creator>Kaufmann, Horacio</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201512</creationdate><title>Progressive retinal structure abnormalities in multiple system atrophy</title><author>Mendoza-Santiesteban, Carlos E. ; Palma, Jose-Alberto ; Martinez, Jose ; Norcliffe-Kaufmann, Lucy ; Hedges III, Thomas R. ; Kaufmann, Horacio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5840-a7d1e317dd1d6260e6792ce60ddfcc18c71a5ec085cffd24a9dae3bf57028d463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Color Perception - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>ganglion cell complex</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>multiple system atrophy</topic><topic>Multiple System Atrophy - pathology</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>optical coherence tomography</topic><topic>Parkinson disease</topic><topic>Retina - pathology</topic><topic>Retina - physiopathology</topic><topic>retinal nerve fiber layer</topic><topic>Tomography, Optical Coherence</topic><topic>unified multiple system atrophy rating scale</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mendoza-Santiesteban, Carlos E.</creatorcontrib><creatorcontrib>Palma, Jose-Alberto</creatorcontrib><creatorcontrib>Martinez, Jose</creatorcontrib><creatorcontrib>Norcliffe-Kaufmann, Lucy</creatorcontrib><creatorcontrib>Hedges III, Thomas R.</creatorcontrib><creatorcontrib>Kaufmann, Horacio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mendoza-Santiesteban, Carlos E.</au><au>Palma, Jose-Alberto</au><au>Martinez, Jose</au><au>Norcliffe-Kaufmann, Lucy</au><au>Hedges III, Thomas R.</au><au>Kaufmann, Horacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive retinal structure abnormalities in multiple system atrophy</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2015-12</date><risdate>2015</risdate><volume>30</volume><issue>14</issue><spage>1944</spage><epage>1953</epage><pages>1944-1953</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>ABSTRACT
Background
Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.
Methods
This was a cross‐sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high‐definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow‐up visits for up to 26 months.
Results
MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (P = 0.008 and P = 0.001) and ganglion cell complex (P = 0.013 and P = 0.001) thicknesses were reduced in MSA and PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 and 1.8 μm, respectively.
Conclusions
Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high‐definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. © 2015 International Parkinson and Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26359930</pmid><doi>10.1002/mds.26360</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Color Perception - physiology Cross-Sectional Studies Disease Progression Female ganglion cell complex Humans Male Middle Aged Movement disorders multiple system atrophy Multiple System Atrophy - pathology Multiple System Atrophy - physiopathology optical coherence tomography Parkinson disease Retina - pathology Retina - physiopathology retinal nerve fiber layer Tomography, Optical Coherence unified multiple system atrophy rating scale Visual Acuity - physiology |
| title | Progressive retinal structure abnormalities in multiple system atrophy |
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