Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker
By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjus...
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Veröffentlicht in: | Advanced materials (Weinheim) 2015-09, Vol.27 (35), p.5158-5164 |
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creator | Van Haute, Desiree Longmate, Julia M. Berlin, Jacob M. |
description | By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au. |
doi_str_mv | 10.1002/adma.201501602 |
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Mater</addtitle><description>By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au.</description><subject>Adjustment</subject><subject>Aggregates</subject><subject>Assembly</subject><subject>Biocompatibility</subject><subject>biocompatible materials</subject><subject>Biocompatible Materials - chemistry</subject><subject>Capping</subject><subject>covalent assembly</subject><subject>Crosslinking</subject><subject>Gold - chemistry</subject><subject>gold nanoparticles</subject><subject>Macrophages</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Micelles</subject><subject>nanoaggregates</subject><subject>nanoclusters</subject><subject>Nanostructure</subject><subject>Nanotechnology - methods</subject><subject>Particle Size</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Uptakes</subject><subject>Water - chemistry</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v00AQxVcIRNPAlSPykYvD7JftvSClAQqoKQioQFxW6_XYLF17w65TyH-Po5SonDjNYX7vzccj5AmFBQVgz03TmwUDKoEWwO6RGZWM5gKUvE9moLjMVSGqE3Ka0g8AUAUUD8kJKxhUlPEZ0aswjDF4j022TAn72u-y0GZnLtjQb8zoao_ZGkfjvbPZpRmC6bqInRkxZVfJDV1msk_91M7WwaPdTvgqhpS8G64xPiIPWuMTPr6tc3L1-tXn1Zv84v3529XyIreSUpa3ULUoaipYW8qitE0tgVdQMSpKg4KWlQAsKwWt4TVV0oDltlW2LnmDjCOfkxcH38227rGxOF1lvN5E15u408E4_W9ncN91F260mMaJ6RVz8uzWIIafW0yj7l2y6L0ZMGyTpqXkQjEl-YQuDqjd3xmxPY6hoPep6H0q-pjKJHh6d7kj_jeGCVAH4JfzuPuPnV6-XC_vmucHrUsj_j5qTbzWRclLqb9cnmv27cOZWH_8qt_xPxGdqhA</recordid><startdate>20150916</startdate><enddate>20150916</enddate><creator>Van Haute, Desiree</creator><creator>Longmate, Julia M.</creator><creator>Berlin, Jacob M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>5PM</scope></search><sort><creationdate>20150916</creationdate><title>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</title><author>Van Haute, Desiree ; Longmate, Julia M. ; Berlin, Jacob M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5112-f08fe4b142f7567cdb5038082147ae417840e7890fa3b195a0c3cf9cb73de23e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adjustment</topic><topic>Aggregates</topic><topic>Assembly</topic><topic>Biocompatibility</topic><topic>biocompatible materials</topic><topic>Biocompatible Materials - chemistry</topic><topic>Capping</topic><topic>covalent assembly</topic><topic>Crosslinking</topic><topic>Gold - chemistry</topic><topic>gold nanoparticles</topic><topic>Macrophages</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Micelles</topic><topic>nanoaggregates</topic><topic>nanoclusters</topic><topic>Nanostructure</topic><topic>Nanotechnology - methods</topic><topic>Particle Size</topic><topic>Sulfhydryl Compounds - chemistry</topic><topic>Uptakes</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Haute, Desiree</creatorcontrib><creatorcontrib>Longmate, Julia M.</creatorcontrib><creatorcontrib>Berlin, Jacob M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Haute, Desiree</au><au>Longmate, Julia M.</au><au>Berlin, Jacob M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. 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source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Adjustment Aggregates Assembly Biocompatibility biocompatible materials Biocompatible Materials - chemistry Capping covalent assembly Crosslinking Gold - chemistry gold nanoparticles Macrophages Metal Nanoparticles - chemistry Micelles nanoaggregates nanoclusters Nanostructure Nanotechnology - methods Particle Size Sulfhydryl Compounds - chemistry Uptakes Water - chemistry |
title | Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker |
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