Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker

By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjus...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Weinheim) 2015-09, Vol.27 (35), p.5158-5164
Hauptverfasser: Van Haute, Desiree, Longmate, Julia M., Berlin, Jacob M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 5164
container_issue 35
container_start_page 5158
container_title Advanced materials (Weinheim)
container_volume 27
creator Van Haute, Desiree
Longmate, Julia M.
Berlin, Jacob M.
description By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au.
doi_str_mv 10.1002/adma.201501602
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4567412</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1753492953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5112-f08fe4b142f7567cdb5038082147ae417840e7890fa3b195a0c3cf9cb73de23e3</originalsourceid><addsrcrecordid>eNqFkc1v00AQxVcIRNPAlSPykYvD7JftvSClAQqoKQioQFxW6_XYLF17w65TyH-Po5SonDjNYX7vzccj5AmFBQVgz03TmwUDKoEWwO6RGZWM5gKUvE9moLjMVSGqE3Ka0g8AUAUUD8kJKxhUlPEZ0aswjDF4j022TAn72u-y0GZnLtjQb8zoao_ZGkfjvbPZpRmC6bqInRkxZVfJDV1msk_91M7WwaPdTvgqhpS8G64xPiIPWuMTPr6tc3L1-tXn1Zv84v3529XyIreSUpa3ULUoaipYW8qitE0tgVdQMSpKg4KWlQAsKwWt4TVV0oDltlW2LnmDjCOfkxcH38227rGxOF1lvN5E15u408E4_W9ncN91F260mMaJ6RVz8uzWIIafW0yj7l2y6L0ZMGyTpqXkQjEl-YQuDqjd3xmxPY6hoPep6H0q-pjKJHh6d7kj_jeGCVAH4JfzuPuPnV6-XC_vmucHrUsj_j5qTbzWRclLqb9cnmv27cOZWH_8qt_xPxGdqhA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753492953</pqid></control><display><type>article</type><title>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Van Haute, Desiree ; Longmate, Julia M. ; Berlin, Jacob M.</creator><creatorcontrib>Van Haute, Desiree ; Longmate, Julia M. ; Berlin, Jacob M.</creatorcontrib><description>By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201501602</identifier><identifier>PMID: 26208123</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Adjustment ; Aggregates ; Assembly ; Biocompatibility ; biocompatible materials ; Biocompatible Materials - chemistry ; Capping ; covalent assembly ; Crosslinking ; Gold - chemistry ; gold nanoparticles ; Macrophages ; Metal Nanoparticles - chemistry ; Micelles ; nanoaggregates ; nanoclusters ; Nanostructure ; Nanotechnology - methods ; Particle Size ; Sulfhydryl Compounds - chemistry ; Uptakes ; Water - chemistry</subject><ispartof>Advanced materials (Weinheim), 2015-09, Vol.27 (35), p.5158-5164</ispartof><rights>2015 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5112-f08fe4b142f7567cdb5038082147ae417840e7890fa3b195a0c3cf9cb73de23e3</citedby><cites>FETCH-LOGICAL-c5112-f08fe4b142f7567cdb5038082147ae417840e7890fa3b195a0c3cf9cb73de23e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201501602$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201501602$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26208123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Haute, Desiree</creatorcontrib><creatorcontrib>Longmate, Julia M.</creatorcontrib><creatorcontrib>Berlin, Jacob M.</creatorcontrib><title>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</title><title>Advanced materials (Weinheim)</title><addtitle>Adv. Mater</addtitle><description>By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au.</description><subject>Adjustment</subject><subject>Aggregates</subject><subject>Assembly</subject><subject>Biocompatibility</subject><subject>biocompatible materials</subject><subject>Biocompatible Materials - chemistry</subject><subject>Capping</subject><subject>covalent assembly</subject><subject>Crosslinking</subject><subject>Gold - chemistry</subject><subject>gold nanoparticles</subject><subject>Macrophages</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Micelles</subject><subject>nanoaggregates</subject><subject>nanoclusters</subject><subject>Nanostructure</subject><subject>Nanotechnology - methods</subject><subject>Particle Size</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Uptakes</subject><subject>Water - chemistry</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v00AQxVcIRNPAlSPykYvD7JftvSClAQqoKQioQFxW6_XYLF17w65TyH-Po5SonDjNYX7vzccj5AmFBQVgz03TmwUDKoEWwO6RGZWM5gKUvE9moLjMVSGqE3Ka0g8AUAUUD8kJKxhUlPEZ0aswjDF4j022TAn72u-y0GZnLtjQb8zoao_ZGkfjvbPZpRmC6bqInRkxZVfJDV1msk_91M7WwaPdTvgqhpS8G64xPiIPWuMTPr6tc3L1-tXn1Zv84v3529XyIreSUpa3ULUoaipYW8qitE0tgVdQMSpKg4KWlQAsKwWt4TVV0oDltlW2LnmDjCOfkxcH38227rGxOF1lvN5E15u408E4_W9ncN91F260mMaJ6RVz8uzWIIafW0yj7l2y6L0ZMGyTpqXkQjEl-YQuDqjd3xmxPY6hoPep6H0q-pjKJHh6d7kj_jeGCVAH4JfzuPuPnV6-XC_vmucHrUsj_j5qTbzWRclLqb9cnmv27cOZWH_8qt_xPxGdqhA</recordid><startdate>20150916</startdate><enddate>20150916</enddate><creator>Van Haute, Desiree</creator><creator>Longmate, Julia M.</creator><creator>Berlin, Jacob M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>5PM</scope></search><sort><creationdate>20150916</creationdate><title>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</title><author>Van Haute, Desiree ; Longmate, Julia M. ; Berlin, Jacob M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5112-f08fe4b142f7567cdb5038082147ae417840e7890fa3b195a0c3cf9cb73de23e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adjustment</topic><topic>Aggregates</topic><topic>Assembly</topic><topic>Biocompatibility</topic><topic>biocompatible materials</topic><topic>Biocompatible Materials - chemistry</topic><topic>Capping</topic><topic>covalent assembly</topic><topic>Crosslinking</topic><topic>Gold - chemistry</topic><topic>gold nanoparticles</topic><topic>Macrophages</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Micelles</topic><topic>nanoaggregates</topic><topic>nanoclusters</topic><topic>Nanostructure</topic><topic>Nanotechnology - methods</topic><topic>Particle Size</topic><topic>Sulfhydryl Compounds - chemistry</topic><topic>Uptakes</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Haute, Desiree</creatorcontrib><creatorcontrib>Longmate, Julia M.</creatorcontrib><creatorcontrib>Berlin, Jacob M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Haute, Desiree</au><au>Longmate, Julia M.</au><au>Berlin, Jacob M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. Mater</addtitle><date>2015-09-16</date><risdate>2015</risdate><volume>27</volume><issue>35</issue><spage>5158</spage><epage>5164</epage><pages>5158-5164</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>By introducing a capping step and controlling the reaction parameters, assembly of metallic nanoparticle aggregates can be achieved using a small‐molecule crosslinker. Aggregates can be assembled from particles of varied size and composition and the size of the aggregates can be systematically adjusted. Following cell uptake of 60 nm aggregates, the aggregates are stable and nontoxic to macrophage cells up to 55 × 10−3m Au.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26208123</pmid><doi>10.1002/adma.201501602</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0935-9648
ispartof Advanced materials (Weinheim), 2015-09, Vol.27 (35), p.5158-5164
issn 0935-9648
1521-4095
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4567412
source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adjustment
Aggregates
Assembly
Biocompatibility
biocompatible materials
Biocompatible Materials - chemistry
Capping
covalent assembly
Crosslinking
Gold - chemistry
gold nanoparticles
Macrophages
Metal Nanoparticles - chemistry
Micelles
nanoaggregates
nanoclusters
Nanostructure
Nanotechnology - methods
Particle Size
Sulfhydryl Compounds - chemistry
Uptakes
Water - chemistry
title Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A50%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Controlled%20Assembly%20of%20Biocompatible%20Metallic%20Nanoaggregates%20Using%20a%20Small%20Molecule%20Crosslinker&rft.jtitle=Advanced%20materials%20(Weinheim)&rft.au=Van%20Haute,%20Desiree&rft.date=2015-09-16&rft.volume=27&rft.issue=35&rft.spage=5158&rft.epage=5164&rft.pages=5158-5164&rft.issn=0935-9648&rft.eissn=1521-4095&rft_id=info:doi/10.1002/adma.201501602&rft_dat=%3Cproquest_pubme%3E1753492953%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1753492953&rft_id=info:pmid/26208123&rfr_iscdi=true