Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors

Ionotropic receptors of γ-aminobutyric acid (GABAAR) regulate neuronal inhibition and are targeted by benzodiazepines and general anesthetics. We show that a fluorescent derivative of α-cobratoxin (α-Ctx), belonging to the family of three-finger toxins from snake venoms, specifically stained the α1β...

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Veröffentlicht in:	The Journal of biological chemistry 2015-09, Vol.290 (37), p.22747-22758
Hauptverfasser:	Kudryavtsev, Denis S., Shelukhina, Irina V., Son, Lina V., Ojomoko, Lucy O., Kryukova, Elena V., Lyukmanova, Ekaterina N., Zhmak, Maxim N., Dolgikh, Dmitry A., Ivanov, Igor A., Kasheverov, Igor E., Starkov, Vladislav G., Ramerstorfer, Joachim, Sieghart, Werner, Tsetlin, Victor I., Utkin, Yuri N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Line, Tumor Cobra Neurotoxin Proteins - chemistry Cobra Neurotoxin Proteins - pharmacology Conotoxins - chemistry Conotoxins - pharmacology Cys-loop receptor Elapidae electrophysiology fluorescence GABAA receptor Mice molecular dynamics Molecular Dynamics Simulation molecular modeling neurotoxin Protein Structure, Secondary Receptors, GABA-A - chemistry Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Signal Transduction snake venom three finger toxin
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