Quantifying cell division with deuterated water and multi-isotope imaging mass spectrometry (MIMS)

Cell division is commonly quantified by the administration of nucleotide labels that are incorporated by the nucleotide salvage pathway. A new approach uses precursors of the de novo nucleotide synthesis pathway, such as labeled water or glucose. Because such precursors are not specific for DNA synt...

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Veröffentlicht in:	Surface and interface analysis 2014-11, Vol.46 (S1), p.161-164
Hauptverfasser:	Steinhauser, Matthew L., Guillermier, Christelle, Wang, Mei, Lechene, Claude P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell division Deoxyribonucleic acid Deuterium DNA synthesis Isotopes Marking MIMS Multi-isotope imaging mass spectrometry NanoSIMS Nucleotides Pathways Precursors SIMS Stable isotope Synthesis
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