Kidney‐Induced Cardiac Allograft Tolerance in Miniature Swine is Dependent on MHC‐Matching of Donor Cardiac and Renal Parenchyma

Kidney allografts possess the ability to enable a short course of immunosuppression to induce tolerance of themselves and of cardiac allografts across a full‐MHC barrier in miniature swine. However, the renal element(s) responsible for kidney‐induced cardiac allograft tolerance (KICAT) are unknown....

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Veröffentlicht in:	American journal of transplantation 2015-06, Vol.15 (6), p.1580-1590
Hauptverfasser:	Madariaga, M. L., Michel, S. G., La Muraglia, G. M., Sekijima, M., Villani, V., Leonard, D. A., Powell, H. J., Kurtz, J. M., Farkash, E. A., Colvin, R. B., Allan, J. S., Cetrulo, Jr, C. L., Huang, C. A., Sachs, D. H., Yamada, K., Madsen, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals basic (laboratory) research / science Graft Rejection - immunology Graft Rejection - prevention & control Heart Heart - physiology Heart Transplantation heart transplantation / cardiology Histocompatibility - immunology Histocompatibility - physiology Immunosuppression Therapy Immunosuppressive Agents - therapeutic use Kidney - physiology Kidney Transplantation kidney transplantation / nephrology Major Histocompatibility Complex - immunology Major Histocompatibility Complex - physiology Models, Animal Swine Swine, Miniature Tacrolimus - therapeutic use Tissue and Organ Procurement tolerance tolerance: mechanisms Transplantation Tolerance - immunology Transplantation Tolerance - physiology
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