Spontaneous and Radiation-Induced Renal Tumors in the Eker Rat Model of Dominantly Inherited Cancer

Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. At the histologic level, RCs develop through multiple stages from early preneoplastic lesions (e.g., atypical tubul...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-01, Vol.90 (1), p.327-331
Hauptverfasser:	Hino, Okio, Andres J. P. Klein-Szanto, Freed, Jerome J., Testa, Joseph R., Brown, Darrell Q., Vilensky, Maria, Yeung, Raymond S., Tartof, Kenneth D., Knudson, Alfred G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Animals Biological and medical sciences Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell lines Cesium Radioisotopes Chromosome Aberrations Chromosome Disorders Chromosome Mapping Chromosomes Chromosomes, Human Crosses, Genetic Embryonic and Fetal Development Female Gamma Rays Gene Deletion Genes Genes, Dominant Genetic inheritance Genetic Linkage Genetic mutation Genetics Homozygote Humans Karyotyping Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Male Medical sciences Mutation Neoplasms, Radiation-Induced - pathology Nephrology. Urinary tract diseases Rats Rats, Inbred BN Rats, Mutant Strains Rodents Tumor cell line Tumor Cells, Cultured Tumor suppressor genes Tumors Tumors of the urinary system
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